Adenosine 3'5'-monophosphate: inhibition of complement-mediated cell lysis.

Science (New York, N.Y.) ·Vol. 183 ·No. 4125 ·1974-02-15 ·Pages 659-61

Kaliner M, Austen KF

Abstract

An increase in adenosine 3',5'-monophosphate (cyclic AMP) in rat mast cells, achieved by stimulating the cells with prostaglandin E(1), by preventing cyclic AMP breakdown with aminophylline, or by adding exogenous dibutyryl cyclic AMP, prevented complement-mediated cytolysis as assessed by both histamine release and vital dye exclusion. Dibutyryl cyclic AMP also suppressed water-induced osmotic lysis.

MeSH Terms

Aminophylline/pharmacology Animals Antigen-Antibody Reactions/drug effects Bucladesine/pharmacology Complement System Proteins Cyclic AMP/biosynthesis,pharmacology Cytotoxicity Tests, Immunologic Histamine Release/drug effects Immunosuppressive Agents/pharmacology In Vitro Techniques Mast Cells/immunology,metabolism Osmotic Fragility/drug effects Prostaglandins/pharmacology Rabbits/immunology Rats Trypan Blue

Chemicals

Immunosuppressive Agents Prostaglandins Aminophylline Bucladesine Complement System Proteins Cyclic AMP Trypan Blue

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kaliner M

Austen K F

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.183.4125.659

Published

1974-02-15

Pages

659-61

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.183.4125.659 View journal details

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Adenosine 3'5'-monophosphate: inhibition of complement-mediated cell lysis.

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