Gaussian Process-Based Multi-Fidelity Bayesian Optimization for Optimal Calibration Point Selection.

Temperature and humidity calibration chambers, which provide controlled environments for instrument testing and validation, are widely applied in the aerospace and biomedicine fields. However, traditional fixed calibration points fail to adapt to complex operational requirements and exhibit problems including a limited coverage range and low efficiency. To address these challenges, this study develops a Gaussian Process-based Multi-Fidelity Bayesian Optimization (GP-MFBO) framework for optimal selection of temperature and humidity calibration points. The framework integrates the following three key components: (1) a three-layer progressive multi-fidelity modeling system comprising physical analytical models, computational fluid dynamics (CFD) numerical simulations, and experimental verification; (2) a systematic uncertainty quantification system covering model uncertainty, parameter uncertainty, and observation uncertainty; and (3) an adaptive acquisition function that balances uncertainty penalty mechanisms and multi-fidelity information gain evaluation. The experimental results demonstrate that the proposed GP-MFBO method achieves optimal calibration point combinations with a temperature uniformity score of 0.149 and humidity uniformity score of 2.38, approaching theoretical optimal solutions within 4.5% and 3.6%, respectively. Compared to standard Gaussian process, Co-Kriging, two-stage optimization, polynomial regression, and traditional single-fidelity methods, GP-MFBO achieves uniformity score improvements of up to 81.7% and 76.3% for temperature and humidity, respectively. The prediction confidence interval coverage reaches 94.2%, outperforming all comparative methods. This research provides a rigorous theoretical foundation and technical solution for the scientific design and reliable operation of large-space temperature and humidity calibration systems.