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PMID: 413461 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Effects of sputum from patients with cystic fibrosis on the activity in vitro of 5 antimicrobial drugs on Pseudomonas aeruginosa.

The American review of respiratory disease ·Vol. 117 ·No. 1 ·1978-01-00 ·Pages 176-8

Davis SD, Bruns WT

Abstract

By in vitro tests on 12 strains of Pseudomonas aeruginosa, sputum from patients with cystic fibrosis sharply increased the minimal bactericidal concentrations of polymyxin B and neomycin. Sputum had a lesser effect on tests with gentamicin and tobramycin and essentially none on tests with carbenicillin.

MeSH Terms
Anti-Bacterial Agents/pharmacology Carbenicillin/pharmacology Cystic Fibrosis Gentamicins/pharmacology Humans Microbial Sensitivity Tests Neomycin/pharmacology Polymyxin B/pharmacology Pseudomonas aeruginosa/drug effects Sputum Tobramycin/pharmacology
Chemicals
Anti-Bacterial Agents Gentamicins Carbenicillin Neomycin Polymyxin B Tobramycin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Davis S D
Bruns W T
Article Info
Journal
The American review of respiratory disease
Abbr.
Am Rev Respir Dis
ISSN
0003-0805
DOI
10.1164/arrd.1978.117.1.176
Published
1978-01-00
Pages
176-8
Language
English
Region
United States
NLM ID
0370523
Subset
IM
External Links
PubMed source DOI: 10.1164/arrd.1978.117.1.176
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