Neonatal tolerance induced by antibody against antigen-specific receptor.

Science (New York, N.Y.) ·Vol. 186 ·No. 4164 ·1974-11-15 ·Pages 640-3

Strayer DS, Cosenza H, Lee WM, Rowley DA, Köhler H

Abstract

Specific immunologic unresponsiveness is induced by injecting adult or neonatal mice with antibody against antigen-specific receptor (antireceptor antibody). Suppression in mice treated as adults lasts several weeks, and cells from these suppressed mice respond normally in culture. In contrast, unresponsiveness induced in neonatal mice is long-lasting; cells from these mice do not respond in culture and do not affect the response of normal cells. Evidently, antireceptor antibody reversibly blocks antigen receptors in adult animals, but induces unresponsiveness in neonatal mice by depleting the clone of receptor-bearing cells.

MeSH Terms

Animals Animals, Newborn/immunology Antibodies, Anti-Idiotypic Binding Sites, Antibody Choline/immunology Clone Cells Epitopes Erythrocytes/immunology Haptens Hemolytic Plaque Technique Horses/immunology Immune Tolerance Immunization Immunization, Passive Immunosuppression Therapy Lymphocytes/immunology Mice Mice, Inbred BALB C Nitrobenzenes/immunology Organophosphorus Compounds/immunology Sheep/immunology Spleen/cytology,immunology

Chemicals

Antibodies, Anti-Idiotypic Epitopes Haptens Nitrobenzenes Organophosphorus Compounds Choline

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Strayer D S

Cosenza H

Lee W M

Rowley D A

Köhler H

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.186.4164.640

Published

1974-11-15

Pages

640-3

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.186.4164.640 View journal details

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Neonatal tolerance induced by antibody against antigen-specific receptor.

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