Serological distinction of mutants B6.CH(zl) and B6.M505 from strain C57BL-6.

The Journal of experimental medicine ·Vol. 140 ·No. 4 ·1974-10-01 ·Pages 1127-32

Klein J, Hauptfeld M, Hauptfeld V

Abstract

A quantitative serological difference was found between strains Hz1 and M505 carrying mutant H-2 haplotypes ba and bd, respectively, and the original strain B6(H-2(b)). The finding suggests that the mutations occurred in the H-2K(b) gene, and together with data on MLR and CML challenges the current concept of H-2 regions' involvement in immune reactions.

MeSH Terms

Animals Antibody Specificity Cytotoxicity Tests, Immunologic Epitopes Genotype Hemagglutination Tests Histocompatibility Antigens Isoantibodies/analysis Lymphocyte Culture Test, Mixed Mice Mice, Inbred C57BL Mutation

Chemicals

Epitopes Histocompatibility Antigens Isoantibodies

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Klein J

Hauptfeld M

Hauptfeld V

References (7)

7 references, click to expand

H-2 types of translocation stocks T(2;9)138Ca, T(9;13)-190Ca and an H-2 recombinant.
Transplantation. 1970 Oct;10(4):309-20 PMID: 4102669
Hemagglutination and cytotoxic studies of H-2. I. H-2.1 and related specificities in the EK crossover regions.
Transplantation. 1971 Mar;11(3):210-37 PMID: 5558558
Cell mediated immunity: separation of cells involved in recognitive and destructive phases.
Science. 1973 Apr 27;180(4084):403-6 PMID: 4267047
Frameshift suppression: a nucleotide addition in the anticodon of a glycine transfer RNA.
Nat New Biol. 1973 Apr 25;242(121):230-4 PMID: 4573868
Cytotoxic lymphocytes in the absence of detectable antibody.
Nat New Biol. 1973 Apr 25;242(121):237-9 PMID: 4540806
The involvement of LD- and SD-region differences in MLC and CML: a three-cell experiment.
Transplant Proc. 1973 Dec;5(4):1651-5 PMID: 4272823
Tissue distribution of I region-associated antigens in the mouse.
J Immunol. 1974 Jul;113(1):181-8 PMID: 4598886

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.140.4.1127

Published

1974-10-01

Pages

1127-32

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2139645

Subset

External Links

PubMed source DOI: 10.1084/jem.140.4.1127 PMC Full Text View journal details

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Serological distinction of mutants B6.CH(zl) and B6.M505 from strain C57BL-6.

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