Abstract
Evidence is presented that ligandin, an intracellular protein involved in the binding of such anions as bilirubin, indocyanine green, and penicillin, is identical to glutathione S-transferase B (EC 2.5.1.18), an enzyme catalyzing the conjugation of glutathione with such electrophiles as 1-chloro-2,4-dinitrobenzene, 1,2-dichloro-4-nitrobenzene, iodomethane, ethacrynic acid, and bromosulfophthalein. The proteins, isolated by distinct methods, have the same specificity for substrates and for ligands, react in identical fashion to antibody produced against ligandin, bear entirely similar physical characteristics and amino acid composition, and are both induced in response to phenobarbital. Indocyanine green, one of the ligands that is not effective as a substrate, was shown to competitively inhibit the conjugation reaction. It is suggested that specificity is directed toward compounds with electrophilic sites.
MeSH Terms
Animals
Bilirubin/metabolism
Binding, Competitive
Carrier Proteins/analysis
Enzyme Activation
Epitopes
Ethacrynic Acid
Glutathione
Indocyanine Green
Kinetics
Ligands
Liver/analysis,enzymology
Methane
Nitrobenzenes
Phenobarbital/pharmacology
Protein Binding
Rats
Transferases/analysis,immunology,metabolism
Chemicals
Carrier Proteins
Epitopes
Ligands
Nitrobenzenes
Transferases
Glutathione
Indocyanine Green
Ethacrynic Acid
Methane
Bilirubin
Phenobarbital
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Habig W H
Pabst M J
Fleischner G
Gatmaitan Z
Arias I M
Jakoby W B
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