Two myeloma globulins, IgG1-kappa and IgG1-lambda, from a single patient (Im). I. Purification and immunochemical characterization.

Immunology ·Vol. 27 ·No. 6 ·1974-12-00 ·Pages 1081-93

Oriol R, Huerta J, Bouvet JP, Liacopoulos P

Abstract

暂无摘要

MeSH Terms

Aged Animals Chemical Precipitation Chromatography, DEAE-Cellulose Cyclophosphamide/therapeutic use Electrophoresis Epitopes Female Hemagglutination Tests Humans Immune Sera Immunochemistry Immunoelectrophoresis Immunoglobulin Fragments Immunoglobulin G/isolation & purification Immunoglobulin Heavy Chains Immunoglobulin kappa-Chains Immunoglobulin lambda-Chains Iodine Radioisotopes Multiple Myeloma/drug therapy,immunology Prednisolone/therapeutic use Rabbits/immunology Ultracentrifugation

Chemicals

Epitopes Immune Sera Immunoglobulin Fragments Immunoglobulin G Immunoglobulin Heavy Chains Immunoglobulin kappa-Chains Immunoglobulin lambda-Chains Iodine Radioisotopes Cyclophosphamide Prednisolone

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Oriol R

Huerta J

Bouvet J P

Liacopoulos P

References (11)

11 references, click to expand

A method of trace iodination of proteins for immunologic studies.
Int Arch Allergy Appl Immunol. 1966;29(2):185-9 PMID: 4160044
Recombination of heavy and light chains of human gamma-a-myeloma proteins: formation of hybrid molecules and configurational specificity.
J Exp Med. 1966 Aug 1;124(2):185-97 PMID: 4162153
Sharing of individual antigenic determinants between a gamma G and a gamma M protein in the same myeloma serum.
Proc Soc Exp Biol Med. 1970 Dec;135(3):660-5 PMID: 4098822
[Preparation of monospecific anti-immunoglobulin antibodies].
Ann Inst Pasteur (Paris). 1968 Jun;114(6):713-26 PMID: 5760428
Restricted structural heterogeneity in antibodies: might different heavy chains have a common light chain?
Nat New Biol. 1972 Dec 13;240(102):215-7 PMID: 4509142
Monoclonal IgA and IgM in the serum of a single patient (SC). I. Sharing of individually specific determinants between IgA and IgM.
J Immunol. 1973 Feb;110(2):335-44 PMID: 4119246
Monoclonal IgA and IgM in the serum of a single patient (SC). 3. Immunofluorescent identification of cells producing IgA and IgM.
J Immunol. 1973 Feb;110(2):350-3 PMID: 4119247
Double myeloma. Production of both IgG type lambda and IgA type lambda myeloma proteins by a single plasma cell line.
Am J Med. 1973 Aug;55(2):215-21 PMID: 4124689
Reduction of gamma-globulins.
Arch Biochem Biophys. 1962 Sep;Suppl 1:174-80 PMID: 13945475
[A micro-method of immuno-electrophoresis].
Int Arch Allergy Appl Immunol. 1955;7(2):103-10 PMID: 13262900
SIMULTANEOUS OCCURRENCE OF TWO IMMUNOLOGICALLY DIFFERENT M-COMPONENTS IN SERUM.
Acta Med Scand. 1965 May;177:593-9 PMID: 14297269

Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1974-12-00

Pages

1081-93

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1445705

Subset

External Links

PubMed source PMC Full Text View journal details

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Two myeloma globulins, IgG1-kappa and IgG1-lambda, from a single patient (Im). I. Purification and immunochemical characterization.

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