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PMID: 4144102 Published · ppublish English Journal Article

Determination of drug metabolizing enzymes in needle biopsies of human liver.

European journal of clinical pharmacology ·Vol. 4 ·No. 2 ·1972-03-00 ·Pages 65-73

Schoene B, Fleischmann RA, Remmer H, von Oldershausen HF

Abstract

暂无摘要

MeSH Terms
Aminopyrine/metabolism Anisoles/metabolism Biopsy Cholinesterases/analysis Cytochrome P-450 Enzyme System/analysis Cytochrome Reductases/analysis Dealkylation Endoplasmic Reticulum/enzymology Glucose-6-Phosphatase/analysis Humans Liver/cytology,enzymology NADP Needles Nitrophenols/metabolism Organ Size Proteins/analysis Spectrophotometry, Ultraviolet
Chemicals
Anisoles Nitrophenols Proteins Aminopyrine NADP Cytochrome P-450 Enzyme System Cytochrome Reductases Cholinesterases Glucose-6-Phosphatase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Schoene B
Fleischmann R A
Remmer H
von Oldershausen H F
References (34)
34 references, click to expand
  1. [The significance of cumulation and elimination for the determination of Phenytoin (diphenylhydantoin)].
    Dtsch Med Wochenschr. 1969 Jun 13;94(24):1265-72 PMID: 5771073
  2. Genetic and environmental factors affecting ethanol metabolism in man.
    Clin Pharmacol Ther. 1971 Mar-Apr;12(2):192-201 PMID: 5102974
  3. [The break-down of pentobarbital in hepatic diseases].
    Klin Wochenschr. 1970 May 1;48(9):565-7 PMID: 5474673
  4. Genetic control of drug levels in man: phenylbutazone.
    Science. 1968 Mar 29;159(3822):1479-80 PMID: 5753556
  5. AN ADAPTIVELY STIMULATED O-DEMETHYLATING SYSTEM IN RAT LIVER MICROSOMES AND ITS KINETIC PROPERTIES.
    J Pharmacol Exp Ther. 1964 Oct;146:61-5 PMID: 14221227
  6. [Quick and simple ultramicromethod for the determination of serum cholinesterase].
    Dtsch Med Wochenschr. 1966 Oct 28;91(43):1927-32 PMID: 5922730
  7. [The activity of N- and O-demethylase in the human liver].
    Biochem Pharmacol. 1970 Feb;19(2):327-42 PMID: 4396246
  8. Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver.
    J Biol Chem. 1962 Feb;237:587-95 PMID: 14007123
  9. Human liver microsomal drug metabolism.
    Biochem Pharmacol. 1970 Apr;19(4):1514-7 PMID: 4398013
  10. About Serum cholinesterase Activity in Liver disease.
    Dtsch Med Wochenschr. 1956 Dec 7;81(49):1959-61 PMID: 13397265
  11. [Increased synthesis and inhibited breakdown during the increase in microsomal cytochromes P-450 and b-5 by phenobarbital].
    Naunyn Schmiedebergs Arch Pharmakol. 1970;266(3):260-75 PMID: 4246569
  12. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.
    J Biol Chem. 1964 Jul;239:2370-8 PMID: 14209971
  13. The fate of aminopyrine (pyramidon) in man and methods for the estimation of aminopyrine and its metabolites in biological material.
    J Pharmacol Exp Ther. 1950 Jun;99(2):171-84 PMID: 15437290
  14. Physiological disposition and chemical fate of thiobarbiturates in the body.
    Fed Proc. 1952 Jun;11(2):632-9 PMID: 14945527
  15. Cytochromes P-450 and b5 in human liver microsomes.
    Clin Pharmacol Ther. 1969 Sep-Oct;10(5):655-9 PMID: 4309140
  16. Kinetic studies of the N-demethylation of ethylmorphine by a cytochrome P-450-dependent enzyme system in human liver microsomes.
    Biochem J. 1971 Mar;122(1):30P PMID: 5124805
  17. Genetic control of drug levels in man: antipyrine.
    Science. 1968 Jul 5;161(3836):72-3 PMID: 5690279
  18. Sex differences in drug metabolism by rat liver microsomes.
    Mol Pharmacol. 1967 Nov;3(6):516-25 PMID: 6059868
  19. [Demethylation of aminophenazone and codeine in human liver. An investigation of microsomal electron transport].
    Biochem Pharmacol. 1970 Jun;19(6):1955-73 PMID: 4398024
  20. The fate of antipyrine in man.
    J Pharmacol Exp Ther. 1950 Jan;98(1):97-104 PMID: 15403625
  21. The microestimation of succinate and the extinction coefficient of cytochrome c.
    Biochim Biophys Acta. 1959 Jul;34:255-6 PMID: 14422133
  22. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  23. [Enzyme activity determination in the human liver. Part 6. Results of studies of 7 additional enzymes of energy-yielding metabolism in the normal and pathologically changed liver. Studies on the protein and blood content of liver punctate].
    Klin Wochenschr. 1959 Dec 1;37:1221-9 PMID: 14443022
  24. [Standardization of red blood pigment by methemoglobin-cyanide. II. Iron content and oxygen binding capacity of human blood].
    Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1956;229(5):450-62 PMID: 13387803
  25. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.
    Biochem J. 1953 Oct;55(3):416-21 PMID: 13105648
  26. [Pharmacokinetics of meprobamate in chronic liver diseases and drug addiction].
    Klin Wochenschr. 1969 Jan 15;47(2):78-80 PMID: 5368643
  27. Phenobarbital: studies of elimination, accumulation, tolerance, and dosage schedules.
    J Pharmacol Exp Ther. 1954 Aug;111(4):425-35 PMID: 13184405
  28. Studies on drug metabolism in human liver.
    Chem Biol Interact. 1971 Aug;3(4):303-4 PMID: 4399905
  29. Persistence of antibiotics in blood of patients with acute renal failure. II. Chloramphenicol and its metabolic products in the blood of patients with severe renal disease or hepatic cirrhosis.
    J Clin Invest. 1959 Sep;38:1498-508 PMID: 14412753
  30. Metabolism of drugs in subjects with Laennec's cirrhosis.
    Med Exp Int J Exp Med. 1959;1:290-2 PMID: 13804621
  31. Phenylbutazone and isoniazid metabolism in patients with liver disease in relation to previous drug therapy.
    Lancet. 1968 Jun 15;1(7555):1275-9 PMID: 4172137
  32. Steady-state plasma levels of nortriptyline in twins: influence of genetic factors and drug therapy.
    Br Med J. 1969 Dec 27;4(5686):764-8 PMID: 5391106
  33. [Effect of carbon tetrachloride on endoplasmic enzymes in rat liver].
    Arch Toxikol. 1971;28(1):1-11 PMID: 4328041
  34. Studies on necrosis of mouse liver in vitro. Alterations in activities of succinoxidase, succinic dehydrogenase, glutamic dehydrogenase, acid phosphatase, uricase, glucose-6-phosphatase and NAD-pyrophosphorylase.
    Am J Pathol. 1965 Nov;47(5):833-50 PMID: 4284754
Article Info
Journal
European journal of clinical pharmacology
Abbr.
Eur J Clin Pharmacol
ISSN
0031-6970
Published
1972-03-00
Pages
65-73
Language
English
Region
Germany
NLM ID
1256165
Subset
IM
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