An abnormality of the alternate pathway of complement activation in sickle-cell disease.

Adolescent Adult Agglutination Tests Anemia, Sickle Cell/immunology Animals Antibodies, Bacterial/analysis Bacterial Infections/etiology Calcium Child Child, Preschool Complement Fixation Tests Complement System Proteins/analysis Glycols/pharmacology Humans Immune Sera Immunoelectrophoresis Immunologic Deficiency Syndromes/etiology Infant Magnesium Opsonin Proteins Phagocytosis Properdin Protein Binding Rabbits/immunology Streptococcus pneumoniae/immunology Zymosan/pharmacology

Antibodies, Bacterial Glycols Immune Sera Opsonin Proteins Properdin Complement System Proteins Zymosan Magnesium Calcium