Regulation of fatty acid synthesis in isolated hepatocytes. Evidence for a physiological role for long chain fatty acyl coenzyme A and citrate.

ATP Citrate (pro-S)-Lyase/antagonists & inhibitors Acetates/metabolism Acetyl Coenzyme A/biosynthesis Acetyl-CoA Carboxylase/antagonists & inhibitors Animals Animals, Newborn Caprylates/metabolism Carbon Dioxide/metabolism Carbon Isotopes Carnitine/pharmacology Chickens Citrates/metabolism Coenzyme A/metabolism Coenzyme A Ligases/metabolism Fatty Acids/biosynthesis Fatty Acids, Nonesterified/pharmacology Liver/drug effects,enzymology,metabolism Microsomes, Liver/enzymology Mitochondria, Liver/enzymology Structure-Activity Relationship Subcellular Fractions/enzymology Tritium

Acetates Caprylates Carbon Isotopes Citrates Fatty Acids Fatty Acids, Nonesterified Tritium Carbon Dioxide Acetyl Coenzyme A ATP Citrate (pro-S)-Lyase Coenzyme A Ligases Acetyl-CoA Carboxylase Carnitine Coenzyme A