Induction of a primary antihapten response in vivo by a graft-vs.-host reaction.

The Journal of experimental medicine ·Vol. 138 ·No. 4 ·1973-10-01 ·Pages 1009-14

Hamilton JA, Miller JF

Abstract

A primary anti-NIP PFC response can be elicited by a GVH reaction provided certain structural requirements of the NIP-carrier are met. NIP-coated F(1) erythrocytes and NIP-coated parental erythrocytes give rise to substantial anti-NIP PFC responses in F(1) mice after the injection of parental spleens. These conjugates do not of themselves give rise to an anti-NIP PFC response and, in fact, normally give rise to NIP-specific tolerance. In contrast the GVH reaction is not able to enhance the primary anti-NIP PFC response to immunogenic NIP-conjugates.

MeSH Terms

Animals Antibody Formation Antibody-Producing Cells Antigens Chickens/immunology Erythrocytes/immunology Graft vs Host Reaction Haptens Immunity, Cellular Iodine Mice Mice, Inbred C57BL Mice, Inbred CBA Nitrophenols Phenylacetates Spleen/cytology,immunology,transplantation Transplantation, Homologous

Chemicals

Antigens Haptens Nitrophenols Phenylacetates Iodine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hamilton J A

Miller J F

References (7)

7 references, click to expand

Chemical and serological studies with an iodine-containing synthetic immunological determinant 4-hydroxy-3-iodo-5-nitrophenylacetic acid (NIP) and related compounds.
Immunology. 1966 May;10(5):465-79 PMID: 5939478
Further improvements in the plaque technique for detecting single antibody-forming cells.
Immunology. 1968 Apr;14(4):599-600 PMID: 5653817
Cell-to-cell interaction in the immune response. VI. Contribution of thymus-derived cells and antibody-forming cell precursors to immunological memory.
J Exp Med. 1971 Jul 1;134(1):66-82 PMID: 5105057
The allogeneic effect in inbred mice. I. Experimental conditions for the enhancement of hapten-specific secondary antibody responses by the graft-versus-host reaction.
J Exp Med. 1972 Sep 1;136(3):439-54 PMID: 4403230
The regulatory influence of activated T cells on B cell responses to antigen.
Adv Immunol. 1972;15:1-94 PMID: 4116319
The allogeneic effect on immune responses: model for regulatory influences of T lymphocytes on the immune system.
Transplant Rev. 1972;12:141-79 PMID: 4405567
The allogeneic effect in inbred mice. 3. Unique antigenic structural requirements in the expression of the phenomenon on unprimed cell populations in vivo.
J Exp Med. 1973 Apr 1;137(4):991-1008 PMID: 4571330

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.138.4.1009

Published

1973-10-01

Pages

1009-14

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2180566

Subset

External Links

PubMed source DOI: 10.1084/jem.138.4.1009 PMC Full Text View journal details

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Induction of a primary antihapten response in vivo by a graft-vs.-host reaction.

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