Amidino-substituted aromatic heterocycles as probes of the specificity pocket of trypsin-like proteases.

Acrosin/antagonists & inhibitors Amidines/pharmacology Animals Binding, Competitive Cattle Endopeptidases/metabolism Factor X/antagonists & inhibitors Fibrinolysin/antagonists & inhibitors Humans Hydrogen-Ion Concentration Kallikreins/antagonists & inhibitors Protease Inhibitors Protein Binding Structure-Activity Relationship Thrombin/antagonists & inhibitors Trypsin Inhibitors

Amidines Protease Inhibitors Trypsin Inhibitors Factor X Endopeptidases Kallikreins Acrosin Thrombin Fibrinolysin