Breakdown of cytochrome P-450 heme by secobarbital and other allyl-containing barbiturates.

Drug metabolism and disposition: the biological fate of chemicals ·Vol. 1 ·No. 1 ·1973-00-00 ·Pages 275-85

Levin W, Jacobson M, Sernatinger E, Kuntzman R

Abstract

暂无摘要

MeSH Terms

Allylisopropylacetamide/pharmacology Animals Barbiturates/pharmacology Carbon Monoxide/metabolism Cytochrome P-450 Enzyme System/metabolism Dose-Response Relationship, Drug Heme/metabolism Male Methylcholanthrene/pharmacology Microsomes, Liver/metabolism Pentobarbital/pharmacology Phenobarbital/pharmacology Porphobilinogen Synthase/metabolism Porphyrins/metabolism Rats Secobarbital/pharmacology Time Factors Tritium

Chemicals

Barbiturates Porphyrins Tritium Secobarbital Allylisopropylacetamide Heme Methylcholanthrene Carbon Monoxide Cytochrome P-450 Enzyme System Porphobilinogen Synthase Pentobarbital Phenobarbital

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Levin W

Jacobson M

Sernatinger E

Kuntzman R

Article Info

Journal

Drug metabolism and disposition: the biological fate of chemicals

Abbr.

Drug Metab Dispos

ISSN

0090-9556

Published

1973-00-00

Pages

275-85

Language

English

Region

United States

NLM ID

9421550

Subset

External Links

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Breakdown of cytochrome P-450 heme by secobarbital and other allyl-containing barbiturates.

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