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PMID: 4154922 Published · ppublish English Journal Article

Effect of progesterone on Neisseria gonorrhoeae.

Infection and immunity ·Vol. 10 ·No. 6 ·1974-12-00 ·Pages 1370-7

Morse SA, Fitzgerald TJ

Abstract

The effects of progesterone on the growth of pathogenic and nonpathogenic species of Neisseria were studied in liquid cultures. Only strains of N. gonorrhoeae and N. meningitidis were highly sensitive to growth inhibition by progesterone. This inhibitory effect was either bacteriostatic or bactericidal, depending upon the ratio of progesterone concentration to cell mass. The site of progesterone inhibition appeared to be located in the cell membrane; >86% of [4-(14)C]progesterone was recovered in the lipid-containing cell fractions. Membrane preparations from N. gonorrhoeae bound progesterone more efficiently than those from progesterone-insensitive cells. In addition, progesterone significantly inhibited the activity of the membrane-associated enzymes reduced nicotinamide adenine dinucleotide oxidase and (cytochrome b) l-lactate dehydrogenase.

MeSH Terms
Bacteriological Techniques Binding Sites Carbon Radioisotopes Cell Membrane/enzymology Culture Media Densitometry Humans L-Lactate Dehydrogenase/metabolism Male NADH, NADPH Oxidoreductases/metabolism Neisseria gonorrhoeae/drug effects,growth & development Progesterone/pharmacology Urethritis/microbiology
Chemicals
Carbon Radioisotopes Culture Media Progesterone L-Lactate Dehydrogenase NADH, NADPH Oxidoreductases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Morse S A
Fitzgerald T J
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24 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.10.6.1370-1377.1974
Published
1974-12-00
Pages
1370-7
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC423113
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.10.6.1370-1377.1974 PMC Full Text View journal details
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