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PMID: 4155692 Published · ppublish English Comparative Study Journal Article

Effects of sulphasalazine (Salazopyrin) on faecal flora in patients with inflammatory bowel disease.

Gut ·Vol. 15 ·No. 12 ·1974-12-00 ·Pages 960-5

West B, Lendrum R, Hill MJ, Walker G

Abstract

The faecal flora of 21 patients with proctocolitis and five patients with Crohn's disease of the large bowel was examined both while sulphasalazine was being administered and during control periods. Patients with proctocolitis and Crohn's disease who were not receiving sulphasalazine had a similar flora which did not differ in any way from the normal. The effect of sulphasalazine was to decrease the numbers of opalescent-negative clostridia, enterobacteria, and total non-sporing anaerobes. It is suggested that this antibacterial effect of sulphasalazine, which has not been previously demonstrated, may be related to the beneficial effects of this drug in proctocolitis and should be investigated further.

MeSH Terms
Adrenal Cortex Hormones/administration & dosage Adrenocorticotropic Hormone/therapeutic use Adult Aged Bacteroides/isolation & purification Clostridium/isolation & purification Colitis/drug therapy,microbiology Crohn Disease/drug therapy,microbiology Enterobacteriaceae/isolation & purification Eubacterium/isolation & purification Feces/microbiology Female Humans Intestine, Large/microbiology Male Middle Aged Prednisone/therapeutic use Proctitis/drug therapy Sulfasalazine/therapeutic use
Chemicals
Adrenal Cortex Hormones Sulfasalazine Adrenocorticotropic Hormone Prednisone
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
West B
Lendrum R
Hill M J
Walker G
References (18)
18 references, click to expand
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Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
DOI
10.1136/gut.15.12.960
Published
1974-12-00
Pages
960-5
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1413081
Subset
IM
External Links
PubMed source DOI: 10.1136/gut.15.12.960 PMC Full Text View journal details
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