Evidence for involvement of 5-hydroxytryptamine in the actions of amphetamine.
1 Pargyline treatment, 1 h before (+)-amphetamine (1 mg/kg), reduced amphetamine-stimulated motor activity. This inhibition was reversed in animals pretreated with p-chlorophenylalanine (PCPA).2 Following treatment with PCPA or 5,6-dihydroxytryptamine (5,6-DHT), amphetamine-induced locomotor activity was significantly potentiated. The increased response to amphetamine in PCPA-treated rats was reversed in animals pretreated with 5-hydroxytryptophan.3 The inhibition of amphetamine-stimulated locomotor activity by treatment with 6-hydroxydopamine was not reversed by PCPA treatment.4 Stereotypies produced by amphetamine were not found to be altered by depletion of 5-hydroxytryptamine.5 Induction of adrenal tyrosine hydroxylase activity produced by chronic amphetamine administration was significantly potentiated by PCPA, emphasizing the involvement of a 5-hydroxytryptamine inhibitory system in more than one action of amphetamine.
26 references, click to expand
-
Adrenal and striatal tyrosine hydroxylase activity after methamphetamine.J Pharmacol Exp Ther. 1973 Apr;185(1):42-8 PMID: 4144311
-
Serotonergic inhibition of catecholamine-induced behavioral arousal.Brain Res. 1973 Jan 30;49(2):381-91 PMID: 4269051
-
Central nervous system mechanisms responsible for blood pressure elevation induced by p-chlorophenylalanine.J Pharmacol Exp Ther. 1972 Apr;181(1):65-74 PMID: 4259017
-
Blockage of amphetamine induced motor stimulation and stereotypy in the adult rat following neonatal treatment with 6-hydroxydopamine.Brain Res. 1973 Jun 15;55(2):369-82 PMID: 4145950
-
MECHANISM OF ACTION OF PSYCHOMOTOR STIMULANT DRUGS. SIGNIFICANCE OF DOPAMINE IN LOCOMOTOR STIMULANT ACTION.Int J Neuropharmacol. 1964 May;3:227-39 PMID: 14336531
-
Selective potentiation of locomotor effects of amphetamine by midbrain raphé lesions.Physiol Behav. 1972 Oct;9(4):655-7 PMID: 4670860
-
Evidence that the central action of amphetamine is mediated via catecholamines.Psychopharmacologia. 1966;9(1):78-80 PMID: 5989105
-
Increase in tyrosine hydroxylase activity after reserpine administration.J Pharmacol Exp Ther. 1969 Sep;169(1):74-9 PMID: 5804613
-
Turnover rate of brain 5-hydroxytryptamine increased by D-amphetamine.Br J Pharmacol. 1970 Nov;40(3):483-91 PMID: 4395745
-
Effects of 6-hydroxydopamine treatments on active avoidance responding: evidence for involvement of brain dopamine.J Pharmacol Exp Ther. 1973 May;185(2):358-70 PMID: 4703827
-
CHLORINATED ARYLALKYLAMINES AFFECTING THE CEREBRAL METABOLISM OF 5-HYDROXYTRYPTAMINE.J Pharmacol Exp Ther. 1964 Sep;145:344-50 PMID: 14214435
-
The role of monoamines in rotation induced or potentiated by amphetamine after nigral, raphe and mesencephalic reticular lesions in the rat brain.Neuropharmacology. 1973 Mar;12(3):195-211 PMID: 4266877
-
p-Chlorophenylalanine: a specific depletor of brain serotonin.J Pharmacol Exp Ther. 1966 Dec;154(3):499-516 PMID: 5297133
-
Amphetamine induced increase in tyrosine hydroxylase activity.Nature. 1970 Jul 4;227(5253):75-6 PMID: 5463606
-
Biochemical and pharmacological effects of the monoamine oxidase inhibitors, iproniazid, 1-phenyl-2-hydrazinopropane (JB 516) and 1-phenyl-3-hydrazinobutane (JB 835).J Pharmacol Exp Ther. 1960 Jan;128:15-21 PMID: 13833205
-
Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for selective degeneration of catecholamine neurons.J Pharmacol Exp Ther. 1970 Sep;174(3):413-20 PMID: 5456173
-
Attenuation of amphetamine-induced motor stimulation and stereotypy by 6-hydroxydopamine in the rat.Br J Pharmacol. 1973 Apr;47(4):683-92 PMID: 4146741
-
Comparison of tyrosine hydroxylase and dopamine-beta-hydroxylase inhibition with the effects of various 6-hydroxydopamine treatments on d-amphetamine induced motor activity.Psychopharmacologia. 1974 Mar 21;36(1):1-16 PMID: 4151923
-
The effect of drugs on the amounts of substance P and 5-hydroxytryptamine in mammalian brain.J Physiol. 1956 Mar 28;131(3):617-26 PMID: 13320358
-
A concept for a role of serotonin and norepinephrine as chemical mediators in the brain.Ann N Y Acad Sci. 1957 Mar 14;66(3):631-42 PMID: 13425246
-
ON THE RELATION OF TRYPTAMINIC AND SEROTONERGIC MECHANISMS TO AMPHETAMINE INDUCED ABNORMAL BEHAVIOUR.Acta Pharmacol Toxicol (Copenh). 1964;21:272-82 PMID: 14209618
-
Evidence that the CCENTRAL ACTION OF (+)-amphetamine is mediated via catecholamines.Psychopharmacologia. 1967;10(4):289-97 PMID: 5592154
-
Depletion of brain noradrenaline and dopamine by 6-hydroxydopamine.Br J Pharmacol. 1971 May;42(1):88-99 PMID: 5580702
-
Differential effects of D- and L-amphetamine on behavior and on catecholamine disposition in dopamine and norepinephrine containing neurons of rat brain.Brain Res. 1971 May 7;28(2):295-309 PMID: 5113521
-
Antiamphetamine effects following inhibition of tyrosine hydroxylase.J Pharmacol Exp Ther. 1966 Mar;151(3):339-52 PMID: 5938473
-
Effects of imipramine, desipramine and monoamine oxidase inhibitors on the metabolism and psychomotor stimulant actions of d-amphetamine in mice.Eur J Pharmacol. 1971 May;14(4):351-9 PMID: 4400534
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