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PMID: 4156289 Published · ppublish English Clinical Trial Comparative Study Controlled Clinical Trial Journal Article Randomized Controlled Trial

Double-blind comparison of the respiratory effects of parenteral lorazepam and diazepam in patients with chronic obstructive lung disease.

Current medical research and opinion ·Vol. 2 ·No. 10 ·1974-00-00 ·Pages 611-5

Denaut M, Yernault JC, De Coster A

Abstract

The effects on the respiratory function of two tranquillising drugs, lorazepam and diazepam, have been compared in 20 patients with chronic obstructive lung disease. Both drugs induce a respiratory depression (decrease in tidal volume and minute ventilation with acceleration of the respiratory frequency) with slight respiratory acidosis, but lorazepam causes no significant hypoxemia and has a shorter duration of action than diazepam. Nevertheless, if tranquillisers are indicated in such patients, they have to be used with care.

MeSH Terms
Acidosis, Respiratory/chemically induced Adult Aged Anti-Anxiety Agents/therapeutic use Bronchitis/blood,drug therapy Carbon Dioxide/blood Chronic Disease Clinical Trials as Topic Diazepam/administration & dosage,adverse effects,therapeutic use Humans Infusions, Parenteral Lorazepam/administration & dosage,adverse effects,therapeutic use Lung Diseases, Obstructive/blood,drug therapy Male Middle Aged Oxygen/blood Respiration/drug effects Spirometry Wakefulness/drug effects
Chemicals
Anti-Anxiety Agents Carbon Dioxide Lorazepam Diazepam Oxygen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Denaut M
Yernault J C
De Coster A
Article Info
Journal
Current medical research and opinion
Abbr.
Curr Med Res Opin
ISSN
0300-7995
DOI
10.1185/03007997409111871
Published
1974-00-00
Pages
611-5
Language
English
Region
England
NLM ID
0351014
Subset
IM
External Links
PubMed source DOI: 10.1185/03007997409111871 View journal details
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