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PMID: 4156831 Published · ppublish English Journal Article

Putrescine catabolism in mammalian brain.

The Biochemical journal ·Vol. 144 ·No. 1 ·1974-10-00 ·Pages 29-35

Seiler N, Al-Therib MJ

Abstract

In contrast with putrescine (1,4-diaminobutane), which is a substrate of diamine oxidase, monoacetylputrescine is oxidatively deaminated both in vitro and in vivo by monoamine oxidase. The product of this reaction is N-acetyl-gamma-aminobutyrate. The existence of a degradative pathway in mammalian brain for putrescine is shown, which comprises acetylation of putrescine, oxidative deamination of monoacetylputrescine to N-acetyl-gamma-aminobutyrate, transformation of N-acetyl-gamma-aminobutyrate to gamma-aminobutyrate and degradation of gamma-aminobutyrate to CO(2) via the tricarboxylic acid cycle.

MeSH Terms
Amine Oxidase (Copper-Containing)/metabolism Animals Brain/metabolism Carbon Dioxide/biosynthesis Carbon Radioisotopes Chromatography, Thin Layer Citric Acid Cycle Electrophoresis Injections Male Mass Spectrometry Mice Mitochondria/metabolism Mitochondria, Liver/metabolism Monoamine Oxidase/metabolism Putrescine/administration & dosage,analogs & derivatives,metabolism Rats Tritium gamma-Aminobutyric Acid/analogs & derivatives
Chemicals
Carbon Radioisotopes Tritium Carbon Dioxide gamma-Aminobutyric Acid Amine Oxidase (Copper-Containing) Monoamine Oxidase Putrescine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Seiler N
Al-Therib M J
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23 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1440029
Published
1974-10-00
Pages
29-35
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1168460
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1440029 PMC Full Text View journal details
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