Activity of tetracycline, doxycycline, and minocycline against methicillin-susceptible and -resistant staphylococci.

Antimicrobial agents and chemotherapy ·Vol. 6 ·No. 4 ·1974-10-00 ·Pages 411-4

Minuth JN, Holmes TM, Musher DM

Abstract

Tetracycline, doxycycline, and minocycline were evaluated for their antibacterial activity against methicillin-susceptible and -resistant isolates of Staphylococcus. At clinically achievable levels both doxycycline and minocycline were more active than tetracycline against methicillin-susceptible organisms. Tetracycline and doxycycline had no activity against methicillin-resistant staphylococci, whereas minocycline at 2 mug/ml inhibited six of 13 strains and, at 3 mug/ml, 10 of 13 strains.

MeSH Terms

Doxycycline/pharmacology Methicillin Resistance/physiology Microbial Sensitivity Tests Minocycline/pharmacology Staphylococcus/drug effects Tetracycline/pharmacology

Chemicals

Tetracycline Minocycline Doxycycline

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Minuth J N

Holmes T M

Musher D M

References (15)

15 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.6.4.411

Published

1974-10-00

Pages

411-4

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC444661

Subset

External Links

PubMed source DOI: 10.1128/AAC.6.4.411 PMC Full Text View journal details

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Activity of tetracycline, doxycycline, and minocycline against methicillin-susceptible and -resistant staphylococci.

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