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PMID: 4159522 Published · ppublish English Journal Article

Elevated gamma-globulin and increased antibody production in mice infected with lactic dehydrogenase virus.

The Journal of experimental medicine ·Vol. 123 ·No. 2 ·1966-02-01 ·Pages 347-64

Notkins AL, Mergenhagen SE, Rizzo AA, Scheele C, Waldmann TA

Abstract

Infection of mice with the lactic dehydrogenase virus (LDV) resulted in an elevated level of gamma-globulin. Histologic examination of the spleen and lymph nodes revealed that the number of germinal centers was greatly increased. Immunization with human gamma-globulin showed that the capacity of the virus-infected animal to produce anti-human gamma-globulin was greatly enhanced and that the virus acted as an adjuvant. From these experiments it is concluded that a virus infection (LDV) can affect the immunologic response of the host to a heterologous antigen.

MeSH Terms
Animals Antibody Formation Hemagglutination Tests Immunoelectrophoresis In Vitro Techniques Iodine Isotopes L-Lactate Dehydrogenase Mice Precipitins RNA Viruses Virus Diseases/immunology gamma-Globulins
Chemicals
Iodine Isotopes Precipitins gamma-Globulins L-Lactate Dehydrogenase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Notkins A L
Mergenhagen S E
Rizzo A A
Scheele C
Waldmann T A
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33 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.123.2.347
Published
1966-02-01
Pages
347-64
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2138136
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.123.2.347 PMC Full Text View journal details
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