Cytotoxic T-cell responses to H-Y: correlation with the rejection of syngeneic male skin grafts.

The Journal of experimental medicine ·Vol. 147 ·No. 3 ·1978-03-01 ·Pages 768-75

Hurme M, Chandler PR, Hetherington CM, Simpson E

Abstract

The ability of female mice to rapidly reject syngenic male skin grafts is largely determined by dominant genes in the IB region of the H-2b halotype, whereas the ability to produce anti-H-Y cytotoxic cells is determined by a dominant gene in the IA region the H-2b halotype, or by complementary genes in the IC region of some other haplotypes. Thus, it seems that H-2-retricted anti-H-Y cytotoxic T cells are not responsible for the rejection of syngeneic male skin grafts.

MeSH Terms

Animals Chromosome Mapping Cytotoxicity, Immunologic Female Genes, Dominant Genes, MHC Class II Graft Rejection H-2 Antigens/genetics Histocompatibility Antigens/genetics Hybridization, Genetic Male Mice Mice, Inbred Strains Skin Transplantation T-Lymphocytes/immunology Transplantation, Homologous Y Chromosome

Chemicals

H-2 Antigens Histocompatibility Antigens

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Hurme M

Chandler P R

Hetherington C M

Simpson E

References (14)

14 references, click to expand

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Y-antigen killing by T cells of women is restricted by HLA.
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Br J Cancer. 1977 Jan;35(1):1-39 PMID: 831755
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Adv Immunol. 1974;18:67-132 PMID: 4151339
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Are there Y-linked histocompatibility antigens in man?
Eur J Immunol. 1974 Jul;4(7):519-20 PMID: 4606241
The genetic basis of male skin rejection in mice.
Transplantation. 1971 Nov;12(5):412-4 PMID: 4948697
Allelic forms of a gene controlling the female immune response to the male antigen in mice.
Transplantation. 1971 Apr;11(4):426-8 PMID: 4934355
A gene governing the female immune response to the male antigen in mice.
Transplantation. 1971 Apr;11(4):404-7 PMID: 4934351
Genetic control of the immune response in mice. 3. An association between H-2 type and reaction to H-Y.
J Immunol. 1971 Mar;106(3):875-6 PMID: 4926269
The effect of allogeneic presensitization on H-Y graft survival and in vitro cell-mediated responses to H-y antigen.
J Exp Med. 1976 Sep 1;144(3):810-20 PMID: 784891
In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.
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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.147.3.768

Published

1978-03-01

Pages

768-75

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2184192

Subset

External Links

PubMed source DOI: 10.1084/jem.147.3.768 PMC Full Text View journal details

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Cytotoxic T-cell responses to H-Y: correlation with the rejection of syngeneic male skin grafts.

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