Antigenic determinants common to human immunoglobulins G and M: importance of conformational antigens.

Antiserums produced against certain isolated human myeloma IgGglobulins and absorbed in order to show only individual antigenic specificity crossreact with certain Waldenstrom IgM-globulins. Some of the common antigenic determinants revealed by these cross-reactions depend on the tertiary and quaternary structure of the IgG and IgM molecules and are independent of their K and L light-chain antigenic types.