Alpha-chain disease: a new immunoglobulin abnormality.

Science (New York, N.Y.) ·Vol. 162 ·No. 3860 ·1968-12-20 ·Pages 1396-7

Seligmann M, Danon F, Hurez D, Mihaesco E, Preud'homme JL

Abstract

A new type of pathological immunoglobulin was found in the serum, urine, and saliva of a young Arab patient with abdominal lymphoma and diffuse lymphoplasmacytic infiltration of the small intestine. This protein is devoid of light chains and is closely related to the alpha polypeptide chains of the gamma(A1) (Le) subclass of immunoglobulin A. It is characterized by electrophoretic heterogeneity, tendency toward polymerization, and a high carbohydrate content. No intracellular synthesis of light chain was detected.

MeSH Terms

Arabia Blood Protein Disorders Chromatography, Gel Female Fucose/analysis Glycoproteins/blood Heavy Chain Disease Hexoses/analysis Humans Immunodiffusion Immunoelectrophoresis Lymphatic Diseases/immunology Lymphoma/immunology Malabsorption Syndromes/immunology Multiple Myeloma/immunology Neoplasm Proteins/analysis Neuraminic Acids/analysis Plasma Cells Ultracentrifugation Whites gamma-Globulins/analysis

Chemicals

Glycoproteins Hexoses Neoplasm Proteins Neuraminic Acids gamma-Globulins Fucose

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Seligmann M

Danon F

Hurez D

Mihaesco E

Preud'homme J L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.162.3860.1396

Published

1968-12-20

Pages

1396-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.162.3860.1396 View journal details

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Alpha-chain disease: a new immunoglobulin abnormality.

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