Limited periods of gene expression in immunoglobulin-synthesizing cells.

Science (New York, N.Y.) ·Vol. 164 ·No. 3887 ·1969-06-27 ·Pages 1524-5

Buell DN, Fahey JL

Abstract

In synchronized human lymphoid cell lines, production of immunoglobulins G and M is greatest during the late Gl and S phases of the cell cycle. Little immunoglobulin appears immediately before, during, and immediately after mitosis. The results indicate that transcription of immunoglobulin genes takes place during a limited part of the mitotic cycle.

MeSH Terms

Burkitt Lymphoma/immunology Cell Line Genetic Code Humans Immunoglobulin G/biosynthesis Immunoglobulin M/biosynthesis Lymphocytes/immunology,metabolism Mitosis Spherocytosis, Hereditary/immunology Spleen/pathology gamma-Globulins/biosynthesis

Chemicals

Immunoglobulin G Immunoglobulin M gamma-Globulins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Buell D N

Fahey J L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.164.3887.1524

Published

1969-06-27

Pages

1524-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.164.3887.1524 View journal details

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