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PMID: 4183777 Published · ppublish English Journal Article

Cells involved in the immune response. XI. Identification of the antigen-reactive cell as the tolerant cell in the immunologically tolerant rabbit.

The Journal of experimental medicine ·Vol. 130 ·No. 1 ·1969-07-01 ·Pages 165-84

Abdou NI, Richter M

Abstract

Rabbits were made immunologically tolerant to either human serum albumin or bovine gamma globulin by the neonatal administration of antigen. At 10 wk of age, they were challenged with the tolerogenic antigen and found to be non-responsive. However, these tolerant rabbits could respond with humoral antibody formation directed toward the tolerogenic antigen if they were treated with normal, allogeneic bone marrow or bone marrow obtained from a rabbit made tolerant toward a different antigen. They were incapable of responding if they were given bone marrow obtained from a rabbit previously made tolerant to the tolerogenic antigen. Irradiated rabbits were unable to respond if treated with tolerant bone marrow, but could respond well if given normal bone marrow. Since it has previously been demonstrated that the antibody-forming cell, in an irradiated recipient of allogeneic bone marrow, is of recipient and not donor origin, the data presented strongly indicate that the unresponsive cell in the immunologically tolerant rabbit is the antigen-reactive cell.

MeSH Terms
Animals Antibody Formation/radiation effects Antigen-Antibody Reactions Antigens Bone Marrow/immunology Bone Marrow Cells Bone Marrow Transplantation Immune Tolerance Rabbits Radiation Effects Serum Albumin Transplantation, Homologous gamma-Globulins
Chemicals
Antigens Serum Albumin gamma-Globulins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Abdou N I
Richter M
References (53)
53 references, click to expand
  1. Cells involved in the immune response. VII. The demonstration, using allotypic markers, of antibody formation by irradiation-resistant cells of irradiated rabbits injected with normal allogeneic bone marrow cells and sheep erythrocytes.
    J Exp Med. 1969 Jun 1;129(6):1261-73 PMID: 4890861
  2. Kinetic study of the production of antibody-forming cells from their precursors.
    Nature. 1968 Jun 15;218(5146):1079-81 PMID: 5656630
  3. Focal antibody production by transferred spleen cells in irradiated mice.
    Science. 1965 Aug 27;149(3687):998-1000 PMID: 5827349
  4. The histophysiology of the antibody response. I. Histogenesis of the plasma cell reaction in rabbit spleen.
    Lab Invest. 1963 Jan;12:106-18 PMID: 13928647
  5. The serum hemolysin response in intact and splenectomized rabbits following immunization by various routes.
    J Infect Dis. 1957 Mar-Apr;100(2):147-61 PMID: 13416649
  6. A new method for the enumeration of antigen-reactive cells responsive to a purified protein antigen.
    J Exp Med. 1969 Feb 1;129(2):371-91 PMID: 5762049
  7. Functions of the spleen in immunity; presidential address.
    Am J Trop Med Hyg. 1956 May;5(3):391-410 PMID: 13327173
  8. Cells involved in the immune response. I. The response of normal rabbit bone marrow cells to antigens in vitro.
    Int Arch Allergy Appl Immunol. 1968;33(5):493-500 PMID: 5657244
  9. Cytodynamics of immune response produced in regional lymph nodes by Salmonella somatic polysaccharide.
    Ann Med Exp Biol Fenn. 1966;44(2):201-8 PMID: 5965842
  10. The X-Y-Z scheme of immunocyte maturation. 3. Early IgM memory and the nature of the memory cell.
    J Immunol. 1967 Apr;98(4):836-43 PMID: 4164560
  11. Evaluation of the direct injection of antigen into a peripheral lymph node for the production of humoral and cell-mediated immunity in the guinea-pig.
    Immunology. 1968 Jul;15(1):65-74 PMID: 5664401
  12. Antibody production by single cells. III. The histology of antibody production.
    Br J Exp Pathol. 1959 Aug;40:301-11 PMID: 14427714
  13. The X-Y-Z scheme of immunocyte maturation. IV. The exhaustion of memory cells.
    J Exp Med. 1968 Feb 1;127(2):307-25 PMID: 5635381
  14. The morphology of antibody-forming cells in the mouse.
    Aust J Exp Biol Med Sci. 1968 Apr;46(2):141-53 PMID: 5656055
  15. The carriage of immunological memory by small lymphocytes in the rat.
    J Exp Med. 1966 Nov 1;124(5):1017-30 PMID: 5926297
  16. The immune response to sheep erythrocytes in the mouse. I. A study of the immunological events utilizing the plaque technique.
    J Exp Med. 1967 Jul 1;126(1):15-33 PMID: 6027644
  17. The immune response to sheep erythrocytes in the mouse. II. A study of the cytological events in the draining lymph node utilizing cellular imprints.
    Immunology. 1968 Sep;15(3):357-69 PMID: 5681593
  18. The ultrastructure and function of the cells in lymph following antigenic stimulation.
    J Exp Med. 1967 Jan 1;125(1):91-110 PMID: 5334544
  19. Neonatal thymectomy and the decrease in antigen-sensitivity of the primary response and immunological "memory" systems.
    Immunology. 1968 Sep;15(3):325-33 PMID: 5681590
  20. The effect of passive antibody on protein synthesis in lymph node cells of immunized rats.
    J Immunol. 1968 Nov;101(5):885-9 PMID: 5748600
  21. Application of a sensitive radial immunodiffusion method for the detection of thyroglobulin autoprecipitins.
    Int Arch Allergy Appl Immunol. 1969;35(4):335-44 PMID: 4976511
  22. Antigen-reactive cells in normal, immunized, and tolerant mice.
    J Exp Med. 1969 Feb 1;129(2):393-410 PMID: 5762050
  23. Differentiation of antibody-forming cells. I. Ratio of precursor cells to antibody-forming cells in the mouse spleen.
    J Immunol. 1968 Jan;100(1):55-60 PMID: 5638317
  24. Distribution of antibody-forming cells of different specificities in the lymph nodes and spleens of guinea pigs.
    J Exp Med. 1968 Oct 1;128(4):729-51 PMID: 4877427
  25. Reversal of post-thymectomy wasting in mice with immunocompetent cells: influence of histocompatibility differences.
    J Immunol. 1969 Jan;102(1):87-92 PMID: 5765460
  26. Immunization of dissociated spleen cell cultures from normal mice.
    J Exp Med. 1967 Sep 1;126(3):423-42 PMID: 6034749
  27. Immunological activity of thymus and thoracic-duct lymphocytes.
    Proc Natl Acad Sci U S A. 1968 Jan;59(1):296-303 PMID: 4873344
  28. REVERSAL OF WASTING IN THYMECTOMIZED MICE BY THE INJECTION OF SYNGENEIC SPLEEN OR THYMUS CELL SUSPENSIONS.
    Nature. 1964 May 16;202:668-70 PMID: 14190029
  29. Immune paralysis of thymus cells by bovine serum albumin.
    Nature. 1968 Nov 9;220(5167):611 PMID: 4301109
  30. The thymus and the precursors of antigen reactive cells.
    Nature. 1967 Nov 18;216(5116):659-63 PMID: 6082462
  31. Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.
    J Exp Med. 1968 Oct 1;128(4):821-37 PMID: 5691986
  32. Primary-type antibody response in vitro.
    Science. 1966 Mar 4;151(3714):1096-8 PMID: 5909782
  33. Differences in the distribution of antigen reactive cells in the lymphoid tissues of the rat and mouse.
    Proc Soc Exp Biol Med. 1969 Jan;130(1):336-8 PMID: 5762521
  34. The fate of parental strain small lymphocytes in F1 hybrid rats.
    Ann N Y Acad Sci. 1962 Oct 24;99:432-55 PMID: 13949633
  35. Cells involved in the immune response. VI. The immune response to red blood cells in irradiated rabbits after administration of normal, primed, or immune allogeneic rabbit bone marrow cells.
    J Exp Med. 1969 Apr 1;129(4):757-74 PMID: 5766947
  36. The mitotic response of thymus-derived cells to antigenic stimulus.
    Transplantation. 1966 Jul;4(4):438-51 PMID: 5967867
  37. Primary stimulation and measurement of antibody production to sheep red blood cells in vitro.
    J Exp Med. 1967 Aug 1;126(2):347-56 PMID: 4165744
  38. Primary induction of plaque forming antibody producing cells in spleen organ culture.
    Proc Soc Exp Biol Med. 1968 Mar;127(3):675-8 PMID: 5651117
  39. Graft-versus-host reactions induced by transplantation of parental strain thymus in neonatally thymectomized F1 hybrid mice.
    Transplantation. 1968 Jul;6(4):514-23 PMID: 4876494
  40. Cells involved in the immune response. X. The transfer of antibody-forming capacity to irradiated rabbits by antigen-reactive cells isolated from normal allogeneic rabbit bone marrow after passage through antigen-sensitized glass bead columns.
    J Exp Med. 1969 Jul 1;130(1):141-63 PMID: 4893095
  41. The proliferative capacity of antigen-sensitive precursors of hemolytic plaque-forming cells.
    J Immunol. 1966 Jun;96(6):973-80 PMID: 5913164
  42. The role of lymphocytes in antibody formation. I. Restoration of the haemolysin response in x-irradiated rats with lymphocytes from normal and immunologically tolerant donors.
    Proc R Soc Lond B Biol Sci. 1967 Sep 12;168(1012):229-43 PMID: 4383552
  43. THE ANTIBODY RESPONSE OF RATS DEPLETED OF LYMPHOCYTES BY CHRONIC DRAINAGE FROM THE THORACIC DUCT.
    J Exp Med. 1963 Jan 31;117(2):303-20 PMID: 19867225
  44. ANTIBODY FORMATION BY RABBIT LYMPH NODE CELLS. II. FURTHER OBSERVATIONS ON THE BEHAVIOR OF SINGLE ANTIBODY-PRODUCING CELLS WITH RESPECT TO THEIR SYNTHETIC CAPACITY AND MORPHOLOGY.
    J Immunol. 1964 Mar;92:346-55 PMID: 14128983
  45. Primary antibody response in organ cultures.
    J Exp Med. 1966 Nov 1;124(5):1001-16 PMID: 5926296
  46. A transplantation assay for mouse cells responsive to antigenic stimulation by sheep erythrocytes.
    Proc Soc Exp Biol Med. 1965 Dec;120(3):868-73 PMID: 5858721
  47. Effect of splenectomy on primary and secondary response to sheep erythrocytes in rats.
    Proc Soc Exp Biol Med. 1967 Feb;124(2):571-3 PMID: 5335652
  48. Immunologic studies of a spontaneous syngeneic tumor-host system. II. Specific immune tolerance and adoptive tolerance by thymic grafts.
    Int Arch Allergy Appl Immunol. 1968;34(6):589-96 PMID: 5759678
  49. The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera.
    J Exp Med. 1951 Feb;93(2):107-20 PMID: 14803635
  50. The immunological reactivity of the thymus.
    Br J Exp Pathol. 1961 Aug;42:379-85 PMID: 13767191
  51. Foci of proliferating antibody-producing cells in a primary immune response in vitro.
    Clin Exp Immunol. 1968 May;3(4):367-72 PMID: 5655473
  52. IMMUNOLOGICAL RECONSTITUTION OF THYMECTOMIZED MICE BY INJECTIONS OF ISOLATED THYMOCYTES.
    Nature. 1964 Feb 22;201:784-6 PMID: 14161202
  53. Cells involved in the immune response. IV. The response of normal and immune rabbit bone marrow and lymphoid tissue lymphocytes to antigens in vitro.
    J Exp Med. 1968 Nov 1;128(5):1099-128 PMID: 4176224
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.130.1.165
Published
1969-07-01
Pages
165-84
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2138669
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.130.1.165 PMC Full Text View journal details
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