Immune responses of inbred mice to repeated low doses of antigen: relationship to histocompatibility (H-2) type.

Science (New York, N.Y.) ·Vol. 168 ·No. 3933 ·1970-05-15 ·Pages 852-4

Vaz NM, Levine BB

Abstract

Immunization of inbred strains of mice with repeated minute doses (0.1 to 1.0 microgram) of hapten-protein conjugates demonstrated wide differences in the magnitude of their antibody responses, which were related to the histocompatibility (H-2) type of the strains. Immunization with a single high dose (100 micrograms) of antigen failed to demonstrate these differences.

MeSH Terms

Animals Antibody Formation Antigens/administration & dosage Dinitrophenols Haptens/administration & dosage,pharmacology Histocompatibility Immunization Immunoglobulin E Inbreeding Mice Mucoproteins Penicillin G Ribonucleases gamma-Globulins

Chemicals

Antigens Dinitrophenols Haptens Mucoproteins gamma-Globulins Immunoglobulin E Ribonucleases Penicillin G

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Vaz N M

Levine B B

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.168.3933.852

Published

1970-05-15

Pages

852-4

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.168.3933.852 View journal details

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Immune responses of inbred mice to repeated low doses of antigen: relationship to histocompatibility (H-2) type.

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