Antigen receptor molecules: inhibition by antiserum against kappa light chains.

Science (New York, N.Y.) ·Vol. 169 ·No. 3944 ·1970-07-31 ·Pages 487-8

Lesley J, Dutton RW

Abstract

Rabbit antiserum against mouse kappa chains, the predominant class of light chains found in mouse immunoglobulins, inhibits the immune response in vitro of mouse spleen cells to erythrocyte antigens. The inhibition becomes irreversible if the mouse spleen cells are treated briefly with both antiserum to kappa chains and complement.

MeSH Terms

Animals Antibody Formation/drug effects Antibody-Producing Cells Antigens Blood Complement System Proteins Depression, Chemical Erythrocytes/immunology Hemolytic Plaque Technique Immune Sera/pharmacology Immunoglobulins In Vitro Techniques Mice Peptides Rabbits Sheep Spleen/cytology,immunology gamma-Globulins

Chemicals

Antigens Immune Sera Immunoglobulins Peptides gamma-Globulins Complement System Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lesley J

Dutton R W

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.169.3944.487

Published

1970-07-31

Pages

487-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.169.3944.487 View journal details

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