The effect of hydrocortisone on immunoglobulin metabolism.

The Journal of clinical investigation ·Vol. 49 ·No. 9 ·1970-09-00 ·Pages 1679-84

Levy AL, Waldmann TA

Abstract

The serum concentration of all subclasses of IgG (gamma(2)A, gamma(2)B, and gamma(1)) as well as IgA and IgM were reduced in normal and low pathogen mice receiving hydrocortisone acetate. Turnover studies using (131)I-labeled gamma(2)A subclass of IgG demonstrated that high dose corticosteroids cause a significantly shortened survival (increased catabolic rate) which contributes to the observed hypogammaglobulinemia. This increase in fractional catabolism is not due to excess loss in the urine or stool but reflects an increase in endogenous catabolism.

MeSH Terms

Agammaglobulinemia Animals Depression, Chemical Gastrointestinal Hemorrhage/metabolism Hydrocortisone/pharmacology Immunoglobulin G/metabolism Immunoglobulin M/metabolism Immunoglobulins/analysis,metabolism Iodine Radioisotopes Iron Isotopes Mice Plasma Volume Proteinuria gamma-Globulins/metabolism

Chemicals

Immunoglobulin G Immunoglobulin M Immunoglobulins Iodine Radioisotopes Iron Isotopes gamma-Globulins Hydrocortisone

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Levy A L

Waldmann T A

References (15)

15 references, click to expand

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Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI106385

Published

1970-09-00

Pages

1679-84

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC322651

Subset

External Links

PubMed source DOI: 10.1172/JCI106385 PMC Full Text View journal details

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The effect of hydrocortisone on immunoglobulin metabolism.

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