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PMID: 4196634 Published · ppublish English Journal Article

Rabies group-specific ribonucleoprotein antigen and a test system for grouping and typing of rhabdoviruses.

Journal of virology ·Vol. 11 ·No. 5 ·1973-05-00 ·Pages 748-55

Schneider LG, Dietzschold B, Dierks RE, Matthaeus W, Enzmann PJ, Strohmaier K

Abstract

Cell-associated ribonucleoprotein (RNP) was isolated from BHK-21 cells infected with several strains of rabies and rabies-related viruses. The RNP-antigen from rabies and related viruses induced the formation of complement-fixing, precipitating, and immunofluorescent antibodies, and proved to be the group-specific antigen common to all rabies viruses. Antigens of the envelope which induce virus-neutralizing antibodies are apparently determinative for the serotype of a virus as evidenced by two-way neutralization tests. A combination of these methods seems to be a useful approach to the serological grouping and typing of rhabdoviruses.

MeSH Terms
Animals Antigens, Viral/isolation & purification Cell Line Centrifugation, Density Gradient Chromatography, Gel Complement Fixation Tests Cricetinae Electrophoresis, Polyacrylamide Gel Fluorescent Antibody Technique Immunodiffusion Immunoelectrophoresis Kidney Methods Mice Microscopy, Electron Neutralization Tests Nucleoproteins/isolation & purification RNA Viruses/classification Rabies virus/growth & development,immunology,pathogenicity Serotyping
Chemicals
Antigens, Viral Nucleoproteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Schneider L G
Dietzschold B
Dierks R E
Matthaeus W
Enzmann P J
Strohmaier K
References (18)
18 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.11.5.748-755.1973
Published
1973-05-00
Pages
748-55
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC355172
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.11.5.748-755.1973 PMC Full Text View journal details
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