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[Electron microscopic and neurochemical study of Alexander's disease (author's transl)].

Etude en microscopie electronique et neurochimique d'un cas de maladie d'Alexander.

Acta neuropathologica ·Vol. 45 ·No. 2 ·1979-02-15 ·Pages 133-40

Escourolle R, de Baecque C, Gray F, Baumann N, Hauw JJ

Abstract

The authors report the results of a cerebral and of a neuromuscular biopsies and of the autopsy findings in another infantile case of Alexander's disease in a girl. They review the 17 previously reported cases of this disease and the various etiopathogenic hypotheses mentioned. The presence of numerous, sometimes abnormal enlarged mitochondria and of abundant membranous cytoplasmic bodies in the astrocytic cytoplasm seems to be unreported elsewhere. Peripheral nerve changes are mentioned for the first time.

MeSH Terms
Astrocytes/ultrastructure Biopsy Brain/ultrastructure Diffuse Cerebral Sclerosis of Schilder/pathology Female Growth Disorders/pathology Humans Infant Intellectual Disability/pathology Microscopy, Electron Mitochondria/ultrastructure Muscles/ultrastructure Peripheral Nerves/ultrastructure Syndrome
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Escourolle R
de Baecque C
Gray F
Baumann N
Hauw J J
References (37)
37 references, click to expand
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Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/BF00691891
Published
1979-02-15
Pages
133-40
Language
fre
Region
Germany
NLM ID
0412041
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00691891 View journal details
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