Fermented Lactobacillus plantarum GKD7 prevents osteoarthritis pain and progression in a preclinical in vivo model.

Osteoarthritis (OA) brought on by aging damages joints and impairs function. Probiotics are known to be safe to eat, and many of them have positive bioactivity for human health issues. Lactobacillus plantarum GKD7 mitigates inflammatory cytokine production and has potential for OA treatment. This study investigated whether fermented GKD7 is effective at preventing the advancement of OA. Anterior cruciate ligament transaction-related bone discomfort and OA are lessened by fermented GKD7. Fermented GKD7 prevented the breakdown of aggrecan and type II collagen alpha 1 chain (COL2A1) by lowering pro-inflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), as well as the chondrolytic factors metalloproteinase-3 (MMP)-3, MMP-13, and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5). This activity prevented cartilage deterioration and bone loss. Our results show that fermented GKD7 improves the prevention of OA formation.