Effects of Selective Retina Therapy on Central Serous Chorioretinopathy with Serous Pigment Epithelial Detachments.

Background/Objective: This study's aim is to evaluate the anatomical and functional effects of selective retina therapy (SRT) in patients with central serous chorioretinopathy (CSC) accompanied by serous pigment epithelial detachment (PED). Methods: This retrospective study included 32 eyes from 32 patients with CSC and serous PED treated with SRT. Pulse energy and micropulse number were adjusted based on test spot visibility on fundus photographs. Best-corrected visual acuity (BCVA; logMAR), central foveal thickness (CFT), subretinal fluid (SRF) height, PED height, and subfoveal choroidal thickness were assessed at baseline and at 1, 2, and 3 months post-treatment. Retinal sensitivity was evaluated using microperimetry at baseline and 3 months. Results: At 3 months after SRT, complete SRF resolution was achieved in 78.1% of eyes (25/32). Mean BCVA improved significantly from 0.29 ± 0.30 logMAR at baseline to 0.20 ± 0.29 logMAR (p = 0.006). Mean CFT decreased from 284.7 ± 91.3 µm to 165.7 ± 94.8 µm (p < 0.001). Mean SRF height decreased from 150.5 ± 74.6 µm to 20.9 ± 48.3 µm (p < 0.001), and mean PED height decreased from 101.7 ± 96.9 µm to 33.3 ± 37.6 µm (p < 0.001). Retinal sensitivity showed a non-significant improvement at 3 months (p = 0.108). Reduction in PED height was moderately correlated with reduction in SRF height (r = 0.446, p = 0.011). Conclusions: SRT was associated with reductions in PED and SRF in CSC. These findings should be interpreted cautiously given the absence of a control group and the potential for spontaneous changes in SRF and PED.