The conversion of C'IS to C'1 esterase by plasmin and trypsin.
The formation of C'1 esterase from C'1, the first component of complement, may be brought about by the action of plasmin or trypsin upon C'1s, a subcomponent of C'1. These enzymes also decrease the esterolytic activity of C'1 esterase. The formation of C'1 esterase was demonstrated by measuring the appearance of an agent or agents with esterolytic properties and the capacity to inactivate C'2 and C'4, attributes of C'1 esterase. The activity of the agent which evolved was blocked by serum inhibitor of C'1 esterase. The implications of these observations, that the formation of C'1 esterase during complement fixation is mediated by proteolytic processes, are under study. The possible inhibition of C'1q by soybean trypsin inhibitor is in agreement with this hypothesis.
21 references, click to expand
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Observations on a pro-esterase associated with partially purified first component of human complement (C'1).Proc Soc Exp Biol Med. 1956 May;92(1):32-7 PMID: 13336065
-
The influence of calcium ions on the inactivation of human complement and its components by plasmin.J Exp Med. 1953 Sep;98(3):277-89 PMID: 13084846
-
Assay and properties of serum inhibitor of C'l-esterase.Proc Soc Exp Biol Med. 1959 Aug-Sep;101:608-11 PMID: 14416422
-
STUDIES ON HUMAN C'1-ESTERASE. I. PURIFICATION AND ENZYMATIC PROPERTIES.J Immunol. 1964 Mar;92:456-67 PMID: 14128991
-
THE MACROMOLECULAR NATURE OF THE FIRST COMPONENT OF HUMAN COMPLEMENT.J Exp Med. 1964 Apr 1;119:593-613 PMID: 14151101
-
Concerning the mechanism of complement action. I. Inhibition of complement activity by diisopropyl fluophosphate.J Immunol. 1956 Dec;77(6):462-8 PMID: 13398627
-
In-vitro and in-vivo studies of a preparation of urokinase.Br Med J. 1963 Apr 6;1(5335):909-15 PMID: 13932245
-
Partial purification and properties of a proteolytic enzyme of human serum.J Biol Chem. 1949 Nov;181(1):431-48 PMID: 15390425
-
Studies on the mechanism of inactivation of human complement by plasmin and by antigen-antibody aggregates. I. The requirement for a factor resembling C'1 and the role of Ca++.J Immunol. 1954 Sep;73(3):146-58 PMID: 13201755
-
Concerning the mechanism of complement action. II. The nature of the first component of guinea pig complement.J Immunol. 1956 Dec;77(6):469-78 PMID: 13398628
-
Purification and biochemical properties of human plasminogen.J Biol Chem. 1960 Apr;235:1005-10 PMID: 14398764
-
INHIBITION OF THE C'-1 COMPONENT OF COMPLEMENT BY AMINO ACIDS.Immunology. 1964 Jul;7:319-31 PMID: 14193148
-
Chromatographic resolution of the first component of human complement into three activities.J Exp Med. 1963 Jun 1;117:983-1008 PMID: 13929797
-
The inactivation of complement and its components by plasmin.J Exp Med. 1953 Apr;97(4):573-89 PMID: 13052820
-
THE DEVELOPMENT OF UROKINASE AS A THROMBOLYTIC AGENT. MAINTENANCE OF A SUSTAINED THROMBOLYTIC STATE IN MAN BY ITS INTRAVENOUS INFUSION.J Lab Clin Med. 1965 May;65:713-31 PMID: 14281368
-
Relative specificity of serologic tests for syphilis in Mycobacterium leprae infection.Am J Clin Pathol. 1957 May;27(5):539-45 PMID: 13435237
-
Studies on the activation of a proesterase associated with partially purified first component of human complement.J Exp Med. 1958 Mar 1;107(3):451-74 PMID: 13513912
-
INCREASED VASCULAR PERMEABILITY INDUCED BY HUMAN PLASMIN.J Exp Med. 1965 Oct 31;122(5):905-21 PMID: 19867295
-
Measurement of the components of complement by the reagent titration technique.Z Immun exp ther. 1959 Oct-Nov;118:358-67 PMID: 13843375
-
Inability of a highly purified streptokinase preparation to inactivate complement in serum.Acta Pathol Microbiol Scand. 1965;64(3):318-28 PMID: 5855583
-
Elution of an esterase from antigen-antibody aggregates treated with human complement.Proc Soc Exp Biol Med. 1956 May;92(1):111-4 PMID: 13336090
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