Cataracts produced by triparanol. (MER-29).

Transactions of the American Ophthalmological Society ·Vol. 65 ·1967-00-00 ·Pages 494-543

Kirby TJ

Abstract

暂无摘要

MeSH Terms

Adult Aged Animals Cataract/chemically induced,congenital,diagnosis,immunology,metabolism,pathology Child Drug Eruptions/etiology Female Folliculitis/chemically induced Fundus Oculi Humans Hypercholesterolemia/drug therapy Ichthyosis/chemically induced Immunoelectrophoresis Lens, Crystalline/pathology Male Middle Aged Rabbits Rats Triparanol/administration & dosage,adverse effects Water-Electrolyte Balance

Chemicals

Triparanol

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Kirby T J

References (23)

23 references, click to expand

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Cataracts in patients treated with triparanol.
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STUDIES ON THE CRYSTALLINE LENS. 13. KINETICS OF POTASSIUM TRANSPORT.
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Mechanism of action of MER-29, an inhibitor of cholesterol biosynthesis.
Biochem Biophys Res Commun. 1960 Jan;2:63-5 PMID: 13795274
Sterol metabolism. I. The occurrence of desmosterol (24-dehydrocholesterol) in rat skin and its conversion in vivo to cholesterol.
J Biol Chem. 1958 May;232(1):347-59 PMID: 13549424
STUDIES ON THE CRYSTALLINE LENS. XI. THE RELATIVE ROLE OF THE EPITHELIUM AND CAPSULE IN TRANSPORT.
Invest Ophthalmol. 1965 Feb;4:104-16 PMID: 14271284
The mechanism of action of MER-29.
Prog Cardiovasc Dis. 1960 May;2:525-30 PMID: 13795275
Lens opacities produced by cataractogenic agents, with special reference to triparanol cataract.
Am J Ophthalmol. 1963 Mar;55:537-41 PMID: 13967174
Biochemistry of the eye. III. Lipids of the lens, cornea, iris, ciliary body, and retina.
AMA Arch Ophthalmol. 1954 May;51(5):596-8 PMID: 13147613
Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29.
J Biol Chem. 1960 Nov;235:3123-6 PMID: 13685286
Distribution of rubidium-86 accumulated in the rabbit lens.
Invest Ophthalmol. 1962 Oct;1:642-5 PMID: 13970096
The electrolyte and water balance of the lens.
Exp Eye Res. 1962 Jun;1:372-84 PMID: 13952931
Effects of MER-29 on the intermediary metabolism of cholesterol.
Prog Cardiovasc Dis. 1960 May;2:511-8 PMID: 13824600
Cataract formation after triparanol therapy.
Arch Ophthalmol. 1962 Oct;68:486-9 PMID: 14456241
Effects of MER-29 on sterol concentration in rat tissues and on cholesterol biosynthesis in vivo and in vitro from mevalonic acid-2-C14.
Prog Cardiovasc Dis. 1960 May;2:492-503 PMID: 13828582
Lethal effect in dogs of prolonged triparanol oral administration.
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A syndrome of dehydration produced by hypocholesteremic agents.
Proc Staff Meet Mayo Clin. 1962 Jan 3;37:1-6 PMID: 14458823
NEW CONCEPTS OF HUMAN LENTICULAR LIPIDS AND THEIR POSSIBLE ROLE IN CATARACTS.
Invest Ophthalmol. 1965 Apr;4:162-6 PMID: 14283008
Accumulation of rubidium-86 by the rabbit lens.
Invest Ophthalmol. 1962 Aug;1:502-6 PMID: 13866307
Cutaneous side effects from use of triparanol (MER-29): preliminary data on ichthyosis and loss of hair.
Proc Staff Meet Mayo Clin. 1961 Apr 26;36:217-28 PMID: 13681223
EFFECTS OF TRIPARANOL (MER-29) ON CHOLESTEROL BIOSYNTHESIS AND ON BLOOD STEROL LEVELS IN MAN.
J Clin Invest. 1961 May;40(5):884-93 PMID: 16695861

Article Info

Journal

Transactions of the American Ophthalmological Society

Abbr.

Trans Am Ophthalmol Soc

ISSN

0065-9533

Published

1967-00-00

Pages

494-543

Language

English

Region

United States

NLM ID

7506106

PMCID

PMC1310282

Subset

External Links

PubMed source PMC Full Text

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