Glycolytic enzymes in adipose tissue of adult diabetics.

British medical journal ·Vol. 3 ·No. 5720 ·1970-08-22 ·Pages 444-5

Galton DJ, Wilson JP

Abstract

The maximal activities of hexokinase and phosphofructokinase were measured in human adipose tissue. Though the mean activity of hexokinase was similar between a group of adult diabetics (n=24) and a group of non-diabetic controls (n=25), in the diabetic group the activity of phosphofructokinase was definitely reduced. Possibly this enzyme deficiency might contribute to impaired glucose utilization by the adipose cell in diabetes.

MeSH Terms

Adipose Tissue/enzymology Adult Diabetes Mellitus/enzymology Hexokinase/analysis,metabolism Humans Phosphofructokinase-1/analysis,metabolism Spectrophotometry

Chemicals

Hexokinase Phosphofructokinase-1

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Galton D J

Wilson J P

References (9)

9 references, click to expand

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Br Med J. 1969 Mar 8;1(5644):616-7 PMID: 5766128
THE EFFECT OF INSULIN ON HUMAN ADIPOSE TISSUE.
Can J Biochem. 1964 Nov;42:1623-35 PMID: 14245256
A defect of glucose utilization in adipose tissue of adult diabetics and in some conditions which may predispose to diabetes.
Clin Sci. 1970 Jun;38(6):661-75 PMID: 4914504
Insulin-resistant diabetes associated with increased endogenous plasma insulin followed by complete remission.
J Clin Invest. 1961 Sep;40:1672-83 PMID: 13699357
New type of needle for obtaining large samples of human adipose tissue.
J Lipid Res. 1967 Jan;8(1):58-60 PMID: 14564707
Protein measurement with the Folin phenol reagent.
J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
The effect of diabetes and insulin in vivo and in vitro on a low Km form of hexokinase from various rat tissues.
Biochem Biophys Res Commun. 1966 Aug 23;24(4):531-6 PMID: 5967240
Effect of alloxan-diabetes on multiple forms of hexokinase in adipose tissue and lung.
Biochem J. 1967 Dec;105(3):1301-5 PMID: 16742560
ENZYME PATTERNS IN HUMAN TISSUES. II. GLYCOLYTIC ENZYME PATTERNS IN NONMALIGNANT HUMAN TISSUES.
Cancer Res. 1964 May;24:722-31 PMID: 14188478

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.3.5720.444

Published

1970-08-22

Pages

444-5

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1701411

Subset

External Links

PubMed source DOI: 10.1136/bmj.3.5720.444 PMC Full Text

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Glycolytic enzymes in adipose tissue of adult diabetics.

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