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PMID: 4256024 Published · ppublish English Journal Article

Effects of alpha-methyl-p-tyrosine, p-chlorophenylalanine, l-beta-(3,4-dihydroxyphenyl)alanine, 5-hydroxytryptophan and diethyldithiocarbamate on the analgesic activity of morphine and methylamphetamine in the mouse.

British journal of pharmacology ·Vol. 42 ·No. 4 ·1971-08-00 ·Pages 512-21

Major CT, Pleuvry BJ

Abstract

1. The analgesic activity of sympathomimetic drugs does not appear to involve a peripheral component.2. Drugs causing changes in morphine analgesia have similar effects on the analgesia produced by methylamphetamine.3. The analgesia produced by morphine and methylamphetamine is increased by drugs which increase the ratio of brain 5-hydroxytryptamine (5-HT) to dopamine.4. The analgesia is decreased by drugs causing a fall in brain 5-HT or a rise in dopamine relative to 5-HT.

MeSH Terms
5-Hydroxytryptophan/pharmacology Acetates/pharmacology Analgesics/antagonists & inhibitors,pharmacology Animals Dihydroxyphenylalanine/pharmacology Drug Synergism Female Fenclonine/pharmacology Injections, Intraperitoneal Male Methamphetamine/antagonists & inhibitors,pharmacology Methyltyrosines/pharmacology Mice Morphine/antagonists & inhibitors,pharmacology Thiocarbamates/pharmacology
Chemicals
Acetates Analgesics Methyltyrosines Thiocarbamates Methamphetamine Dihydroxyphenylalanine Morphine 5-Hydroxytryptophan Fenclonine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Major C T
Pleuvry B J
References (20)
20 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1971.tb07137.x
Published
1971-08-00
Pages
512-21
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1665735
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1971.tb07137.x PMC Full Text View journal details
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