Double donut versus filament: How structural shapes regulate SPOP activity and cancer pathogenesis.

Molecular cell ·第 86 卷 ·第 15 期 ·2026-08-06

Glennie L, Huang DT

摘要

In this issue of Molecular Cell, Cuneo et al.1 propose an equilibrium between two quaternary states of SPOP that can become dysregulated in cancer. SPOP oligomers form inactive double donuts or active linear filaments, as seen in gain-of-function cancer mutations.

文献信息

期刊

Molecular cell

期刊简称

Mol Cell

ISSN

1097-4164

DOI

10.1016/j.molcel.2026.07.010

发表日期

2026-08-06

语言

英语

国家/地区

United States

NLM ID

9802571

外部链接

PubMed 原文 DOI: 10.1016/j.molcel.2026.07.010 查看期刊详情

分析服务

Double donut versus filament: How structural shapes regulate SPOP activity and cancer pathogenesis.

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