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PMID: 4261591 Published · ppublish English Journal Article

Spontaneous atherosclerosis in pigeons. A model system for studying metabolic parameters associated with atherogenesis.

The American journal of pathology ·Vol. 67 ·No. 1 ·1972-04-00 ·Pages 1-22

Santerre RF, Wight TN, Smith SC, Brannigan D

Abstract

The interpretation of metabolic studies related to early changes in spontaneous atherosclerosis has been hampered by the focal nature of the disease and by the lack of a well-defined model system of the disease process. Gross, histologic and ultrastructural observations of lesion development at the celiac bifurcation of the aorta in atherosclerosis-susceptible White Carneau and atherosclerosis-resistant Show Racer pigeons are compared and discussed in terms of hemodynamics, muscular aggregation and altered metabolism of smooth muscle cells. Detailed knowledge of the morphologic sequence of events in lesion localization makes the celiac bifurcation in White Carneau and Show Racer pigeons a useful model for genetic comparisons of arterial wall metabolism and for investigating metabolic alterations occurring with atherogenesis.

MeSH Terms
Animals Aorta/metabolism,pathology Arteriosclerosis/enzymology,metabolism,pathology,physiopathology Columbidae Disease Models, Animal Glycosaminoglycans/metabolism Hemodynamics Lipid Metabolism Microscopy, Electron Muscle, Smooth/metabolism,pathology,physiopathology
Chemicals
Glycosaminoglycans
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Santerre R F
Wight T N
Smith S C
Brannigan D
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28 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1972-04-00
Pages
1-22
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC2032587
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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