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PMID: 4265117 Published · ppublish English Journal Article

A modle for active transport of sodium and potassium ions as mediated by a tetrameric enzyme.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 70 ·No. 1 ·1973-01-00 ·Pages 275-8

Stein WD, Lieb WR, Karlish SJ, Eilam Y

Abstract

A new model is proposed for the system that actively transports sodium and potassium ions across animal-cell membranes. The model is based on the physical and chemical properties of transport-associated adenosine triphosphatase (EC 3.6.1.3) and on the kinetics of ion movements mediated by the system. Transport is postulated to occur by internal transfer of cations across a protein tetramer embedded in the cell membrane. The protein tetramer can exist in either of two forms of identical energy; transport occurs as a result of the sequential "flipping" from one conformation to the other. The conformation change results in the interchanging of the affinities of cation-binding sites associated with different sub-units of the tetramer, with a concomitant splitting of adenosine triphosphate.

MeSH Terms
Adenosine Triphosphatases/metabolism Binding Sites Biological Transport, Active Cell Membrane Permeability Kinetics Models, Biological Potassium/metabolism Sodium/metabolism
Chemicals
Sodium Adenosine Triphosphatases Potassium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Stein W D
Lieb W R
Karlish S J
Eilam Y
References (19)
19 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.70.1.275
Published
1973-01-00
Pages
275-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC433230
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.70.1.275 PMC Full Text View journal details
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