Selective allele loss in mixed infections with T4 bacteriophage.
Evidence is presented that when E. coli B is mixedly infected with T4D wild type and rII deletion mutants, the excess DNA of the wild type allele is lost. No loss is seen in mixed infections with rII point mutants and wild type. In similar experiments with lysozyme addition mutants, the mutant allele is lost. We believe these results demonstrate a repair system which removes "loops" in heteroduplex DNA molecules. A number of phage and host functions have been tested for involvement in the repair of the excess DNA, and T4 genes x and v have been implicated in this process.
18 references, click to expand
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Mapping of deletions and substitutions in heteroduplex DNA molecules of bacteriophage lambda by electron microscopy.Science. 1969 Mar 21;163(3873):1343-8 PMID: 5765116
-
Effects of deletion mutations on high negative interference in T4D bacteriophage.Genetics. 1969 Sep;63(1):1-5 PMID: 5365292
-
Differential transmission of amber and wild-type alleles of bacteriophage T4 in mixedly infected cells of Escherichia coli.Virology. 1970 May;41(1):52-65 PMID: 4910440
-
Mutants of phage T4 with increased sensitivity to ultraviolet.Virology. 1963 Jan;19:66-71 PMID: 13952844
-
Replication and recombination of DNA fragments in bacteriophage T4.Cold Spring Harb Symp Quant Biol. 1968;33:361-9 PMID: 4891976
-
Chromosome structure in phage T4, II. Terminal redundancy and heterozygosis.Proc Natl Acad Sci U S A. 1965 Nov;54(5):1333-9 PMID: 4222403
-
High Negative Interference over Short Segments of the Genetic Structure of Bacteriophage T4.Genetics. 1958 May;43(3):332-53 PMID: 17247760
-
Dark repair of ultraviolet-irradiated deoxyribonucleic acid by bacteriophage T4: purification and characterization of a dimer-specific phage-induced endonuclease.J Bacteriol. 1971 May;106(2):500-7 PMID: 4929862
-
The identification of complex genotypes in bacteriophage T4. I. Methods.Genetics. 1970 Nov;66(3):417-28 PMID: 4933468
-
ICR-induced frameshift mutations in the histidine operon of Salmonella.J Bacteriol. 1970 Feb;101(2):490-504 PMID: 4905310
-
The nature of the "deletion" mutants in the rII region of phage T4.J Mol Biol. 1961 Oct;3:684-92 PMID: 14480261
-
Hycanthone: a frameshift mutagen.Science. 1971 Jun 4;172(3987):1058-60 PMID: 5573958
-
Genetic analysis of T4D phage heterozygotes produced in the presence of 5-fluorodeoxyuridine.Genetics. 1965 Oct;52(4):729-46 PMID: 4220468
-
Genetic control of mutation rates in bacteriophageT4.Nature. 1969 Mar 22;221(5186):1128-32 PMID: 4975273
-
Altered amino acid sequences produced by reversion of frameshift mutants of tryptophan synthetase A gene of E. coli.Proc Natl Acad Sci U S A. 1967 Oct;58(4):1499-506 PMID: 4867662
-
Frameshift mutation in the lysozyme gene of bacteriophage T4: demonstration of the insertion offour bases and the preferential occurrence of base addition in acridine mutagenesis.J Mol Biol. 1970 Dec 14;54(2):199-217 PMID: 4924202
-
Frameshift mutation in the lysozyme gene of bacteriophage T4: demonstration of the insertion of five bases, and a summary of in vivo codons and lysozyme activities.J Mol Biol. 1970 Dec 14;54(2):219-46 PMID: 5494033
-
Heteroduplex heterozygotes in bacteriophage T4 involving mutations of various dimensions.Proc Natl Acad Sci U S A. 1966 Mar;55(3):506-12 PMID: 5221235
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