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PMID: 4267314 Published · ppublish English Journal Article

Ouabain: temporal relationship between the inotropic effect and the in vitro binding to, and dissociation from, (Na + + K + )- activated ATPase.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 277 ·No. 2 ·1973-00-00 ·Pages 151-62

Akera T, Baskin SI, Tobin T, Brody TM

Abstract

暂无摘要

MeSH Terms
Adenosine Triphosphatases/antagonists & inhibitors,metabolism Animals Binding Sites Cats Chemical Phenomena Chemistry Dogs Enzyme Activation Guinea Pigs Heart/drug effects,physiology In Vitro Techniques Myocardium/enzymology Ouabain/pharmacology Perfusion Potassium/pharmacology Rabbits Sodium/pharmacology Species Specificity Tritium
Chemicals
Tritium Ouabain Sodium Adenosine Triphosphatases Potassium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Akera T
Baskin S I
Tobin T
Brody T M
References (32)
32 references, click to expand
  1. An allosteric explanation for ouabain-induced time-dependent inhibition of sodium, potassium-adenosine triphosphatase.
    Arch Biochem Biophys. 1970 Nov;141(1):322-8 PMID: 4249246
  2. Subcellular distribution of digoxin-H3 in isolated guinea-pig and rat hearts.
    J Pharmacol Exp Ther. 1968 Feb;159(2):324-34 PMID: 5638654
  3. Correlation of cardiac sodium- and potassium-activated adenosine triphosphatase activity with ouabain-induced inotropic stimulation.
    J Pharmacol Exp Ther. 1970 May;173(1):145-51 PMID: 4245610
  4. Influence of extracellular potassium concentration on myocardial uptake and inotropic effect of tritiated digoxin.
    Circ Res. 1971 Mar;28(3):337-45 PMID: 5545900
  5. Factors that regulate ouabain-H3 accumulation by the isolated guinea-pig heart.
    J Pharmacol Exp Ther. 1969 Dec;170(2):318-25 PMID: 5355984
  6. Inhibition of binding of tritiated digoxin to myocardium by sodium depletion in dogs.
    Circ Res. 1969 Feb;24(2):263-8 PMID: 5764586
  7. The correlation between the decline of the positive inotropic effect and the loss of cardiac glycosides from isolated atria during wash-out.
    Eur J Pharmacol. 1969;6(3):235-40 PMID: 5799185
  8. Species and ionic influences on the accumulation of digitalis glycosides by isolated perfused hearts.
    Br J Pharmacol. 1972 Nov;46(3):401-8 PMID: 4656603
  9. [On the cause of species differences in digitalis sensitivity].
    Biochem Pharmacol. 1965 Dec;14(12):1785-802 PMID: 4222534
  10. The asymmetrical stimulation of a membrane adenosine triphosphatase in relation to active cation transport.
    Biochem J. 1962 Jul;84:110-8 PMID: 14006660
  11. The red cell membrane and the transport of sodium and potassium.
    Am J Med. 1966 Nov;41(5):666-80 PMID: 5332167
  12. The binding of tritiated ouabain to sodium- and potassium-activated adenosine triphosphatase and cardiac relaxing system of perfused dog heart.
    Mol Pharmacol. 1970 Jul;6(4):441-3 PMID: 4246826
  13. [Liability of different cardenolides on papillary muscle and on microsomal ATPase of guinea pig hearts].
    Naunyn Schmiedebergs Arch Pharmakol. 1971;268(2):200-9 PMID: 4250812
  14. Rates of dissociation of enzyme-ouabain complexes and K 0.5 values in (Na + + K + ) adenosine triphosphatase from different species.
    Biochem Pharmacol. 1972 Jun 1;21(11):1553-60 PMID: 4265025
  15. Relationship among contraction, drug binding and positive inotropic action of digoxin.
    J Pharmacol Exp Ther. 1970 Feb;171(2):249-55 PMID: 5459061
  16. THE RELATIONSHIP BETWEEN PHOSPHORUS METABOLISM AND THE SODIUM PUMP IN INTACT CRAB NERVE.
    Biochim Biophys Acta. 1963 Sep 24;75:287-9 PMID: 14083916
  17. Membrane adenosine triphosphatase. The effect of potassium on the formation and dissociation of the ouabain-enzyme complex.
    J Pharmacol Exp Ther. 1971 Mar;176(3):545-57 PMID: 4255765
  18. Mutual exclusion of ATP, ADP and g-strophanthin binding to NaK-ATPase.
    Nat New Biol. 1971 Nov 24;234(47):122-4 PMID: 4257111
  19. Correlation between the inotropic action of ouabain and its effects on subcellular enzyme systems from canine myocardium.
    J Pharmacol Exp Ther. 1970 Jan;171(1):1-12 PMID: 4243705
  20. Possible involvement of cardiac Na+, K+-adenosine triphosphatase in the mechanism of action of cardiac glycosides.
    J Pharmacol Exp Ther. 1969 Jul;168(1):31-41 PMID: 4240030
  21. The nature of the transport ATPase-digitalis complex. II. Some species differences and ouabain "exchange" characteristics.
    J Mol Cell Cardiol. 1971 Dec;3(3):297-300 PMID: 4378066
  22. Influence of potassium depletion on myocardial concentration of tritiated digoxin.
    Circ Res. 1967 May;20(5):473-6 PMID: 6057680
  23. On the positive inotropic action of alkylating bromoacetates of strophanthidin and strophanthidol-[19-H3].
    J Pharmacol Exp Ther. 1970 Jan;171(1):13-9 PMID: 4243704
  24. The effect of ouabain on sodium- and potassium-activated adenosine triphosphatase from the hearts of several mammalian species.
    J Pharmacol Exp Ther. 1969 Nov;170(1):17-26 PMID: 4242640
  25. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  26. Species and tissue differences in the rate of dissociation of ouabain from (Na+ + K+)-ATPase.
    Biochim Biophys Acta. 1972 Aug 9;274(2):551-5 PMID: 4261811
  27. A possible biochemical explanation for the insensitivity of the rat to cardiac glycosides.
    J Pharmacol Exp Ther. 1969 Jul;168(1):42-6 PMID: 4240031
  28. [The effect of strophanthidin-3-bromacetate on the papillary muscle of guinea pig hearts].
    Naunyn Schmiedebergs Arch Pharmakol. 1971;268(2):192-9 PMID: 4250811
  29. Quantitative aspects of the interaction between ouabain and (Na + + K + )-activated ATPase in vitro.
    Biochim Biophys Acta. 1971 Oct 12;249(1):53-62 PMID: 4258793
  30. Tritiated digoxin binding to (Na+ + K+)-activated adenosine triphosphatase: possible allosteric site.
    Science. 1968 Apr 19;160(3825):323-5 PMID: 4230510
  31. Mechanism of cardiac glycoside inhibition of the (Na+-K+)-dependent ATPase from cardiac tissue.
    Biochim Biophys Acta. 1968 Mar 25;151(3):655-63 PMID: 4230809
  32. Potassium ions and the binding of cardiac glycosides to mammalian cells.
    Nature. 1970 May 9;226(5245):521-3 PMID: 5442345
Article Info
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Abbr.
Naunyn Schmiedebergs Arch Pharmacol
ISSN
0028-1298
DOI
10.1007/BF00501156
Published
1973-00-00
Pages
151-62
Language
English
Region
Germany
NLM ID
0326264
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00501156 View journal details
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