Treatment of gonorrheal urethritis with spectinomycin hydrochloride.

Canadian Medical Association journal ·Vol. 110 ·No. 2 ·1974-01-19 ·Pages 173 passim

Brown J, Tabert O, Hanna JD, Rentiers PL

Abstract

One hundred and eighty-seven males with uncomplicated gonorrheal urethritis were treated with spectinomycin hydrochloride in a dosage of 2 g. given intramuscularly. A failure rate of 3.2% was observed and no complications of therapy were encountered. In addition, 310 strains of N. gonorrhoeae were tested for susceptibility to penicillin G and spectinomycin. All strains were sensitive to 20 mug./ml. of spectinomycin and this susceptibility appeared to decrease as penicillin resistance increased. A greater incidence of relative resistance to penicillin G was observed than in similar studies from other Canadian areas.

MeSH Terms

Evaluation Studies as Topic Follow-Up Studies Gonorrhea/drug therapy Humans Male Microbial Sensitivity Tests Neisseria gonorrhoeae/drug effects,isolation & purification Penicillin G/pharmacology Penicillin Resistance Spectinomycin/pharmacology,therapeutic use Urethra/microbiology Urethritis/drug therapy

Chemicals

Spectinomycin Penicillin G

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Brown J

Tabert O

Hanna J D

Rentiers P L

References (17)

17 references, click to expand

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Article Info

Journal

Canadian Medical Association journal

Abbr.

Can Med Assoc J

ISSN

0008-4409

Published

1974-01-19

Pages

173 passim

Language

English

Region

Canada

NLM ID

0414110

PMCID

PMC1947120

Subset

External Links

PubMed source PMC Full Text

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Treatment of gonorrheal urethritis with spectinomycin hydrochloride.

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