In vitro versus in vivo metabolic activation of mutagens.

Environmental health perspectives ·Vol. 6 ·1973-12-00 ·Pages 71-82

Malling HV, Frantz CN

Abstract

暂无摘要

MeSH Terms

Adenine Animals Enzyme Induction/drug effects Formaldehyde/toxicity Genes/drug effects Genetics, Microbial Histidine Hydroxylation Kinetics Methods Mice Mice, Inbred Strains Microsomes, Liver/drug effects,enzymology,metabolism Mutagens Mutation Neurospora crassa Nitrosamines/metabolism Oxidoreductases, N-Demethylating/metabolism Proadifen/pharmacology Rats Salmonella typhimurium Species Specificity

Chemicals

Mutagens Nitrosamines Formaldehyde Histidine Proadifen Oxidoreductases, N-Demethylating Adenine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Malling H V

Frantz C N

References (12)

12 references, click to expand

Correlation between base-pair transition and complementation pattern in nitrous acid-induced ad-3B mutants of Neurospora crassa.
Mutat Res. 1968 May-Jun;5(3):359-71 PMID: 5727269
Monooxygenase drug metabolizing activity in CaCl 2 -aggregated hepatic microsomes from rat liver.
Biochem Biophys Res Commun. 1972 May 12;47(3):611-8 PMID: 4402636
Inhibition of drug metabolism. I. Kinetics of the inhibition of the N-demethylation of ethylmorphine by 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF 525-A) and related compounds.
Mol Pharmacol. 1966 Jul;2(4):319-27 PMID: 5968071
Relations between complementation patterns and genetic alterations in nitrous acid-induced ad-3B mutants of Neurospora crassa.
Mutat Res. 1967 Jul-Aug;4(4):425-40 PMID: 6059024
Increased renal carcinogenesis by dimethyl nitrosamine in protein deficient rats.
Br J Exp Pathol. 1970 Dec;51(6):587-90 PMID: 5493138
Identification of genetic alterations induced by ethyl methanesulfonate in Neurospora crassa.
Mutat Res. 1968 Sep-Oct;6(2):181-93 PMID: 5714159
Dimethylnitrosamine: formation of mutagenic compounds by interaction with mouse liver microsomes.
Mutat Res. 1971 Dec;13(4):425-9 PMID: 4401365
Nitrosamine-induced carcinogenesis. The alklylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate.
Biochem J. 1968 Nov;110(1):39-47 PMID: 5722690
A host-mediated microbial assay for the detection of mutagenic compounds.
Proc Soc Exp Biol Med. 1969 Mar;130(3):831-4 PMID: 4886528
Peroxides and the induction of mutations by x-rays, ultraviolet, and formaldehyde.
Radiat Res. 1963;Suppl 3:171-83 PMID: 13989775
Protein measurement with the Folin phenol reagent.
J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
The mutagenic action of formaldehyde on bacteria.
J Bacteriol. 1952 Jan;63(1):1-11 PMID: 14927543

Article Info

Journal

Environmental health perspectives

Abbr.

Environ Health Perspect

ISSN

0091-6765

DOI

10.1289/ehp.730671

Published

1973-12-00

Pages

71-82

Language

English

Region

United States

NLM ID

0330411

PMCID

PMC1475552

Subset

External Links

PubMed source DOI: 10.1289/ehp.730671 PMC Full Text View journal details

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In vitro versus in vivo metabolic activation of mutagens.

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