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PMID: 4293082 Published · ppublish English Journal Article

Role of S-adenosylmethionine in methionine biosynthesis in yeast.

Journal of bacteriology ·Vol. 94 ·No. 4 ·1967-10-00 ·Pages 966-71

Botsford JL, Parks LW

Abstract

Extracts of Saccharomyces cerevisiae were used to develop a cell-free system capable of converting the beta-carbon of serine into the methyl group of methionine. No requirement for either S-adenosylmethionine or S-adenosylhomocysteine could be demonstrated for net methionine biosynthesis. Growth of the cells in B(12) did not affect the reaction. The mechanism for the methylation of homocysteine in yeast appears to be similar to the non-B(12) system in Escherichia coli.

MeSH Terms
Adenine Nucleotides/pharmacology Carbon Isotopes Cell-Free System Culture Media Escherichia coli/metabolism Ethanol/pharmacology Flavin-Adenine Dinucleotide/pharmacology Hexosephosphates/pharmacology Homocysteine/pharmacology Magnesium/pharmacology Methionine/biosynthesis,pharmacology NAD/pharmacology Nucleosides/pharmacology Pyridoxal Phosphate/pharmacology Saccharomyces/metabolism Serine/pharmacology
Chemicals
Adenine Nucleotides Carbon Isotopes Culture Media Hexosephosphates Nucleosides Homocysteine NAD Flavin-Adenine Dinucleotide Ethanol Serine Pyridoxal Phosphate Methionine Magnesium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Botsford J L
Parks L W
References (23)
23 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.94.4.966-971.1967
Published
1967-10-00
Pages
966-71
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC276763
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.94.4.966-971.1967 PMC Full Text View journal details
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