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PMID: 429967 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Structural studies on the murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion.

The Journal of experimental medicine ·Vol. 149 ·No. 4 ·1979-04-01 ·Pages 981-6

Cook RG, Vitetta ES, Uhr JW, Capra JD

Abstract

The E/C alpha- and beta-subunits of intra-I-region recombinants were analyzed for primary structural variation by comparative tryptic peptide mapping. The E/C alpha-polypeptides from B10.A, B10.A (3R) and B10.A (5R) showed complete coincident elution of peptides; the E/C beta-chains from B10.A and 3R (or 5R) were approximately 40% different. This suggests that the structural gene for the E/C beta-polypeptide is within the I-A subregion.

MeSH Terms
Amino Acid Sequence Animals Antigens, Surface/genetics Genes Isoantigens/genetics Macromolecular Substances Major Histocompatibility Complex Mice Peptide Fragments/analysis
Chemicals
Antigens, Surface Isoantigens Macromolecular Substances Peptide Fragments
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Cook R G
Vitetta E S
Uhr J W
Capra J D
References (11)
11 references, click to expand
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    Nature. 1978 Oct 26;275(5682):762-4 PMID: 81469
  2. Genetic control of specific immune responses and immune suppressions by I-region genes.
    Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:465-75 PMID: 70301
  3. Genetics and serology of HL-A-linked human Ia antigens.
    Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:443-55 PMID: 70300
  4. Two-gene control of the expression of a murine Ia antigen.
    J Exp Med. 1978 Oct 1;148(4):925-39 PMID: 100572
  5. Studies on the protein products of murine chromosome 17:a status report.
    Transplant Proc. 1978 Dec;10(4):695-9 PMID: 104414
  6. Analysis of H-2 and Ia molecules by two-dimensional gel electrophoresis.
    J Exp Med. 1977 Nov 1;146(5):1261-79 PMID: 411873
  7. Serological and functional evidence for further subdivision of the I regions of the H-2 gene complex.
    Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:477-87 PMID: 302172
  8. Structural studies on the murine IA alloantigens. II. Molecular weight characterization of the products of the I-A and I-E/C subregions.
    J Immunol. 1978 Dec;121(6):2205-12 PMID: 722075
  9. Histocompatibility-linked immune response genes.
    Science. 1972 Jan 21;175(4019):273-9 PMID: 4109878
  10. The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.
    Adv Immunol. 1975;20:125-95 PMID: 47219
  11. Structural and serological properties of murine Ia alloantigens.
    Transplant Rev. 1976;30:236-70 PMID: 59974
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.149.4.981
Published
1979-04-01
Pages
981-6
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2184847
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.149.4.981 PMC Full Text View journal details
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