Histone phosphorylation: stimulation by adenosine 3',5'-monophosphate.

Science (New York, N.Y.) ·Vol. 162 ·No. 3853 ·1968-11-01 ·Pages 579-80

Langan TA

Abstract

Adenosine cyclic 3',5'-monophosphate at a concentration of 10-(7)M causes a four-to sixfold increase in the rate of histone phosphorylation catalyzed by a liver enzyme preparation. This observation suggests a mechanism for the induction of RNA synthesis by those hormones that cause increases in the concentration of cyclic AMP.

MeSH Terms

Adenine Nucleotides/pharmacology Cyclic AMP/pharmacology Histones/metabolism Hormones/physiology Hydrogen-Ion Concentration Liver/enzymology Phosphates/metabolism Phosphorus Isotopes Phosphotransferases/metabolism RNA/biosynthesis Stimulation, Chemical

Chemicals

Adenine Nucleotides Histones Hormones Phosphates Phosphorus Isotopes RNA Cyclic AMP Phosphotransferases

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Langan T A

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.162.3853.579

Published

1968-11-01

Pages

579-80

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.162.3853.579 View journal details

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Histone phosphorylation: stimulation by adenosine 3',5'-monophosphate.

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