Polyoma virus gene activity during lytic infection and in transformed animal cells.

Science (New York, N.Y.) ·Vol. 164 ·No. 3875 ·1969-04-04 ·Pages 68-70

Martin MA, Axelrod D

Abstract

Randomly labeled RNA's from animal cells either productively infected or transformed by polyoma virus were used to measure virus DNA transcription. During lytic infection, 50 percent of polyoma virus DNA was expressed. In two different polyoma-transformed hamster cell lines, the same 20 percent of the virus genome was transcribed. About 10 percent of polyoma DNA was expressed in the one mouse transformed cell line examined.

MeSH Terms

Animals Carbon Isotopes Cell Transformation, Neoplastic Centrifugation, Density Gradient Cricetinae Culture Techniques Cytopathogenic Effect, Viral DNA, Viral/metabolism Embryo, Mammalian/cytology Genetic Code Genetics, Microbial Hybridization, Genetic Mice Neoplasms, Experimental/etiology Phosphorus Isotopes Polyomavirus/pathogenicity RNA, Viral/metabolism

Chemicals

Carbon Isotopes DNA, Viral Phosphorus Isotopes RNA, Viral

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Martin M A

Axelrod D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.164.3875.68

Published

1969-04-04

Pages

68-70

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.164.3875.68 View journal details

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Polyoma virus gene activity during lytic infection and in transformed animal cells.

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