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PMID: 4307716 Published · ppublish English Journal Article

Virus-specific nucleic acids in SV40-exposed hamster embryo cell lines: correlation with S and T antigens.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 62 ·No. 2 ·1969-02-00 ·Pages 589-96

Levin MJ, Oxman MN, Diamandopoulos GT, Levine AS, Henry PH, Enders JF

Abstract

A number of homologous SV40-exposed hamster embryonic cell lines were examined for the presence of RNA complementary to SV40 DNA. Only those lines containing the SV40 T antigen were found to have such virus-specific RNA. In lines containing the SV40 S antigen, but not the SV40 T antigen, virus-specific RNA was not detected. These findings suggest that the S antigen is not coded for directly by the SV40 genome.

MeSH Terms
Animals Antigens/analysis Cell Transformation, Neoplastic Cricetinae Culture Techniques DNA, Viral Embryo, Mammalian Hybridization, Genetic Neoplasms, Experimental/immunology RNA, Viral/analysis Simian virus 40 Tritium
Chemicals
Antigens DNA, Viral RNA, Viral Tritium
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Levin M J
Oxman M N
Diamandopoulos G T
Levine A S
Henry P H
Enders J F
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22 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.62.2.589
Published
1969-02-00
Pages
589-96
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC277849
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.62.2.589 PMC Full Text View journal details
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