Slow-reacting substance of anaphylaxis: studies on purification and characterisation.

Agents and actions. Supplements ·No. 6 ·1979-00-00 ·Pages 27-36

Morris HR, Taylor GW, Piper PJ, Tippins JR

Abstract

We have demonstrated the role of arachidonic acid and lipoxygenase in the genesis of SRS-A and the possible role of lipoxygenases in its metabolism. SRS-A has been purified in microgram quantities together with closely related material. We have identified 5,12 di-hydroxy-6, 8, 10, 14 eicosatetranenoic acid released by antigen challenge, and which we feel is related to SRS-A. Further structural work is in progress.

MeSH Terms

Animals Arachidonic Acids/metabolism Autacoids/isolation & purification,pharmacology Bronchi/drug effects Fatty Acids/pharmacology Guinea Pigs Humans Ileum/drug effects Indomethacin/pharmacology Lipoxygenase/metabolism Muscle Contraction/drug effects Trachea/drug effects

Chemicals

Arachidonic Acids Autacoids Fatty Acids Lipoxygenase Indomethacin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Morris H R

Taylor G W

Piper P J

Tippins J R

Article Info

Journal

Agents and actions. Supplements

Abbr.

Agents Actions Suppl

ISSN

0379-0363

DOI

10.1007/978-3-0348-7232-4_3

Published

1979-00-00

Pages

27-36

Language

English

Region

Switzerland

NLM ID

7801014

Subset

External Links

PubMed source DOI: 10.1007/978-3-0348-7232-4_3

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Slow-reacting substance of anaphylaxis: studies on purification and characterisation.

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