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PMID: 4308099 Published · ppublish English Journal Article

Differences in the transfer RNA's of normal liver and Novikoff hepatoma.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 62 ·No. 3 ·1969-03-00 ·Pages 899-905

Baliga BS, Borek E, Weinstein IB, Srinivasan PR

Abstract

-A comparison of the elution profiles of 18 aminoacyl-tRNA's from Novikoff hepatoma with those from normal liver on a methylated albuminkieselguhr column revealed the occurrence of new species of tRNA for histidine, tyrosine, and asparagine in the hepatoma. In addition, the hepatoma tRNA's for arginine, isoleucine, lysine, methionine, serine, alanine, and tryptophan eluted at a higher salt concentration than the corresponding tRNA's of normal liver. The remaining eight amino acids did not show any significant differences in the elution profiles.

MeSH Terms
Amino Acids Animals Asparagine Carbon Isotopes Carcinoma, Hepatocellular Chromatography Histidine Ligases Liver/analysis Liver Neoplasms Methods Neoplasms, Experimental RNA, Transfer/analysis Rats Tritium Tyrosine
Chemicals
Amino Acids Carbon Isotopes Tritium Tyrosine Histidine Asparagine RNA, Transfer Ligases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Baliga B S
Borek E
Weinstein I B
Srinivasan P R
References (19)
19 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.62.3.899
Published
1969-03-00
Pages
899-905
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC223683
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.62.3.899 PMC Full Text View journal details
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